Recent Advances in Pharmacotherapy Development for Abdominal Aortic Aneurysm

Figure 3

Regression of abdominal aortic aneurysm (AAA) with c-Jun N-terminal kinase (JNK) inhibitor in a mouse model. Six weeks after stimulation of mouse aorta with CaCl₂, the AAA model was established in association with elastic lamellae disruption and increased aortic diameter. After AAA establishment, pharmacologic treatment with SP600125, a JNK inhibitor, was initiated. After six weeks of SP600125 treatment, there was a significant reduction in aneurysmal size compared with vehicle treatment as well as before treatment. The regression of AAA was accompanied by a repair of tissue architecture. EVG: elastica Van Gieson (modified from Yoshimura et al. [36]).