MicroRNAs in Vascular Biology

Figure 2

miRNAs regulate ECs functions. Schematic summary of endothelial miRNAs implicated in vascular inflammation. Senescence associated miRNA regulates SIRT1 or PI3K signaling. miRNAs directly involving in inflammatory response regulate angiotensin II signaling, redox signaling, and adhesion molecules. miR-146a suppresses NADPH oxidative subunit NOX4 expression [43]. Proangiogenic miRNAs (miR-23, -27, 210, 126, 130a, 296) and antiangiogenic miRNAs (miR-17, -92, -132) are also important for endothelial homeostasis [44–46].