Table 4: Selected values of positive and negative predictive value (PPV, NPV) leading to improved prognosis of patients with either neurological symptoms or plaque instability.

Neurol. symptomsPlaque instability
AUC*PPV*NPV*AUC*PPV*NPV*

MMP-1n.c.n.c.n.c.0.69179.655.3
MMP-70.63949.369.20.61576.245.8
MMP-90.63752.567.50.67479.250.9
TIMP-10.65156.464.90.65479.148.3

MMP-1 + MMP-7n.c.n.c.n.c.n.c.n.c.n.c.
MMP-1 + MMP-9n.c.n.c.n.c.n.c.n.c.n.c.
MMP-1 + TIMP-1n.c.n.c.n.c.n.c.n.c.n.c.
MMP-7 + MMP-90.68454.980.10.70481.653.8
MMP-7 +TIMP-10.68165.168.90.69881.653.8
MMP-9 + TIMP-10.68762.269.60.71383.755.8

MMP-1 + MMP-7 + MMP-90.66162.269.60.71486.454.4
MMP-1 + MMP-7 + TIMP-10.65561.468.40.72779.759.5
MMP-1 + MMP-9 + TIMP-10.66760.872.1n.c.n.c.n.c.
MMP-7 + MMP-9 + TIMP-10.70761.174.50.72380.152.9

MMP-1 + MMP-7 + MMP-9 + TIMP-10.67260.273.90.72986.454.4

*AUC: area under curve; only values with statistical significance are shown; n.c.: no further increase in positive (PPV) and negative (NPV) predictive value.