Evaluation of Serum Biomarkers for Patients at Increased Risk of Stroke
Table 4
Selected values of positive and negative predictive value (PPV, NPV) leading to improved prognosis of patients with either neurological symptoms or plaque instability.
Neurol. symptoms
Plaque instability
AUC*
PPV*
NPV*
AUC*
PPV*
NPV*
MMP-1
n.c.
n.c.
n.c.
0.691
79.6
55.3
MMP-7
0.639
49.3
69.2
0.615
76.2
45.8
MMP-9
0.637
52.5
67.5
0.674
79.2
50.9
TIMP-1
0.651
56.4
64.9
0.654
79.1
48.3
MMP-1 + MMP-7
n.c.
n.c.
n.c.
n.c.
n.c.
n.c.
MMP-1 + MMP-9
n.c.
n.c.
n.c.
n.c.
n.c.
n.c.
MMP-1 + TIMP-1
n.c.
n.c.
n.c.
n.c.
n.c.
n.c.
MMP-7 + MMP-9
0.684
54.9
80.1
0.704
81.6
53.8
MMP-7 +TIMP-1
0.681
65.1
68.9
0.698
81.6
53.8
MMP-9 + TIMP-1
0.687
62.2
69.6
0.713
83.7
55.8
MMP-1 + MMP-7 + MMP-9
0.661
62.2
69.6
0.714
86.4
54.4
MMP-1 + MMP-7 + TIMP-1
0.655
61.4
68.4
0.727
79.7
59.5
MMP-1 + MMP-9 + TIMP-1
0.667
60.8
72.1
n.c.
n.c.
n.c.
MMP-7 + MMP-9 + TIMP-1
0.707
61.1
74.5
0.723
80.1
52.9
MMP-1 + MMP-7 + MMP-9 + TIMP-1
0.672
60.2
73.9
0.729
86.4
54.4
*AUC: area under curve; only values with statistical significance are shown; n.c.: no further increase in positive (PPV) and negative (NPV) predictive value.
