Thrombophilic Genetic Factors PAI-1, MTHFRC677T, V Leiden 506Q, and Prothrombin 20210A in Noncirrhotic Portal Vein Thrombosis and Budd-Chiari Syndrome in a Caucasian Population

Table 2

Frequencies of thrombophilic genetic factors (THRGFs), PAI-1 4G-4G, MTHFR677TT, V Leiden 506Q, and Prothrombin 20210A, in patients with abdominal thrombosis (AT) and healthy controls (HC). Frequencies in patients with portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS) are separately reported.

	PVT (%)	BCS (%)	(A) AT (%)	(B) HC (%)	OR (95% CI); (A) versus (B)	𝜒^2 test: 𝑃 value; (A) versus (B)
Number of patients	54 (100)	31 (100)	85 (100)	150 (100)	—	—
PAI-1 4G-4G	30 (55.5)	17 (54.8)	47 (55.3)	26 (17.3)	6.8 (3.5–13.2)	41.3: 𝑃<0.000
MTHFR677TT	16 (28.6)	8 (25.8)	24 (28.2)	20 (13.3)	2.6 (1.3–5.3)	7.9: 𝑃=0.005
V Leiden 506Q	4 (7.4)	9 (29.0)	13 (15.3)	7 (4.6)	3.7 (1.3–10.8)	7.9: 𝑃=0.005
Prothrombin 20210A	4 (7.4)	1 (3.2)	5 (5.8)	4 (2.6)	2.3 (0.5–2.4)	1.5: 𝑃=0.2
>1 THRGF	10 (18.5)	5 (16.2)	15 (17.6)	2 (1.3)	15.9 (3.3–103.4)	21.5: 𝑃<0.000
At least 1 THRGF	44 (81.5)	30 (96.7)	73 (87.1)	54 (36.0)	10.8 (5.2–23.1)	54.4: 𝑃<0.000