Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE^−/− Mice

Figure 3

Concentration-response curves to the endothelium-dependent vasodilator acetylcholine (ACh) in aorta from WT (○) and fat-fed ApoE^−/− mice. ApoE^−/− mice are untreated (●) or chronically treated with 10 (▲) or 100 (▾) μmol/kg/day NaHS or PPG 30 mg/kg/day (◆). Untreated fat-fed ApoE^−/− mice had significantly attenuated response to ACh (𝑅_max and EC₅₀) (^#,Ψ𝑃<0.05, 𝑡-test, WT versus fat-fed ApoE^−/−). Fat-fed ApoE^−/− treated with NaHS at either dose had improved relaxation responses (𝑅_max and EC₅₀) to ACh (^∗,Φ𝑃<0.05, ANOVA untreated, versus treated), 𝑛=5--7.