Studies on the Pinctada fucata BMP-2 Gene: Structural Similarity and Functional Conservation of Its Osteogenic Potential within the Animal Kingdom

Figure 5

Pairwise sequence alignment of PfBMP-2 and human BMP-2. The residue numbers indicate the positions of the amino acids in the BMP-2 precursor before processing. The closed box indicates the human BMP-2 functional domain (the knuckle epitope of human BMP-2). The bold underline indicates the synthetic polypeptides for examining the osteogenic activity of PfBMP-2. : denotes identical residues in two BMP-2 orthologs; • denotes a moderately conserved residue.