Review Article
The Human Vaginal Bacterial Biota and Bacterial Vaginosis
Table 2
Limitations of Koch’s postulates.
| Ignore the
contribution of host, vector, and environment to disease susceptibility/response | Colonization
state (e.g., +PPD skin test for tuberculosis in the absence of disease)
violates Koch’s second postulate | Many pathogens cannot be
propagated on lifeless (cell-free) medium in the lab; these pathogens cannot
fulfill Koch’s third postulate | Viruses, parasites, uncultivated
bacteria may not grow in pure culture | Host range restriction of
pathogens | Do not consider the possibility
of disease produced by a microbial community rather than a single pathogen | Not completely specific |
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