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Linked References

1. K. M. Flegal, M. D. Carroll, C. L. Ogden, and C. L. Johnson, “Prevalence and trends in obesity among US adults, 1999-2000,” The Journal of the American Medical Association, vol. 288, no. 14, pp. 1723–1727, 2002.
2. W. P. T. James, “The epidemiology of obesity: the size of the problem,” Journal of Internal Medicine, vol. 263, no. 4, pp. 336–352, 2008. View at Publisher · View at Google Scholar · View at PubMed
3. V. Amber and S. R. Bloom, “Adiposity and the gut—the role of gut hormones,” Current Nutrition & Food Science, vol. 3, no. 1, pp. 75–90, 2007.
4. H. Tilg and A. R. Moschen, “Adipocytokines: mediators linking adipose tissue, inflammation and immunity,” Nature Reviews Immunology, vol. 6, no. 10, pp. 772–783, 2006. View at Publisher · View at Google Scholar · View at PubMed
5. M. Zeyda and T. M. Stulnig, “Adipose tissue macrophages,” Immunology Letters, vol. 112, no. 2, pp. 61–67, 2007. View at Publisher · View at Google Scholar · View at PubMed
6. G. Frühbeck, “Intracellular signalling pathways activated by leptin,” Biochemical Journal, vol. 393, no. 1, pp. 7–20, 2006. View at Publisher · View at Google Scholar · View at PubMed
7. S. Aleffi, I. Petrai, C. Bertolani, et al., “Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells,” Hepatology, vol. 42, no. 6, pp. 1339–1348, 2005. View at Publisher · View at Google Scholar · View at PubMed
8. A. Bellisari, “Evolutionary origins of obesity,” Obesity Reviews, vol. 9, no. 2, pp. 165–180, 2008. View at Publisher · View at Google Scholar · View at PubMed
9. L. A. Moreno, M. C. Ochoa, J. Wärnberg, A. Marti, J. A. Martínez, and A. Marcos, “Treatment of obesity in children and adolescents. How nutrition can work?,” International Journal of Pediatric Obesity, vol. 3, pp. 72–77, 2008. View at Publisher · View at Google Scholar · View at PubMed
10. N. P. Hays, P. R. Galassetti, and R. H. Coker, “Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions,” Pharmacology & Therapeutics, vol. 118, no. 2, pp. 181–191, 2008. View at Publisher · View at Google Scholar · View at PubMed
11. S. R. Gill, M. Pop, R. T. DeBoy, et al., “Metagenomic analysis of the human distal gut microbiome,” Science, vol. 312, no. 5778, pp. 1355–1359, 2006. View at Publisher · View at Google Scholar · View at PubMed
12. G. Reid, M. E. Sanders, H. R. Gaskins, et al., “New scientific paradigms for probiotics and prebiotics,” Journal of Clinical Gastroenterology, vol. 37, no. 2, pp. 105–118, 2003. View at Publisher · View at Google Scholar
13. Y. Sanz, I. Nadal, and E. Sánchez, “Probiotics as drugs against human gastrointestinal infections,” Recent Patents on Anti-Infective Drug Discovery, vol. 2, no. 2, pp. 148–156, 2007.
14. M. Medina, E. Izquierdo, S. Ennahar, and Y. Sanz, “Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications,” Clinical & Experimental Immunology, vol. 150, no. 3, pp. 531–538, 2007. View at Publisher · View at Google Scholar · View at PubMed
15. P. D. Cani, R. Bibiloni, C. Knauf, et al., “Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice,” Diabetes, vol. 57, no. 6, pp. 1470–1481, 2008.
16. R. A. Rastall and V. Maitin, “Prebiotics and synbiotics: towards the next generation,” Current Opinion in Biotechnology, vol. 13, no. 5, pp. 490–496, 2002. View at Publisher · View at Google Scholar
17. R. E. Ley, F. Bäckhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, and J. I. Gordon, “Obesity alters gut microbial ecology,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 31, pp. 11070–11075, 2005. View at Publisher · View at Google Scholar · View at PubMed
18. R. E. Ley, P. J. Turnbaugh, S. Klein, and J. I. Gordon, “Microbial ecology: human gut microbes associated with obesity,” Nature, vol. 444, no. 7122, pp. 1022–1023, 2006. View at Publisher · View at Google Scholar · View at PubMed
19. P. J. Turnbaugh, F. Bäckhed, L. Fulton, and J. I. Gordon, “Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome,” Cell Host & Microbe, vol. 3, no. 4, pp. 213–223, 2008. View at Publisher · View at Google Scholar · View at PubMed
20. M. Li, B. Wang, M. Zhang, et al., “Symbiotic gut microbes modulate human metabolic phenotypes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 6, pp. 2117–2122, 2008. View at Publisher · View at Google Scholar · View at PubMed
21. M. Kalliomäki, M. C. Collado, S. Salminen, and E. Isolauri, “Early differences in fecal microbiota composition in children may predict overweight,” American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 534–538, 2008.
22. M. Wabitsch, “Overweight and obesity in European children and adolescents: causes and consequences, treatment and prevention: an introduction,” European Journal of Pediatrics, vol. 159, no. 1, pp. S5–S7, 2000.
23. S. Fanaro, R. Chierici, P. Guerrini, and V. Vigi, “Intestinal microflora in early infancy: composition and development,” Acta Paediatrica, vol. 91, no. 441, pp. 48–55, 2003. View at Publisher · View at Google Scholar
24. S. H. Duncan, A. Belenguer, G. Holtrop, A. M. Johnstone, H. J. Flint, and G. E. Lobley, “Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces,” Applied and Environmental Microbiology, vol. 73, no. 4, pp. 1073–1078, 2007. View at Publisher · View at Google Scholar · View at PubMed
25. R. E. Ley, M. Hamady, C. Lozupone, et al., “Evolution of mammals and their gut microbes,” Science, vol. 320, no. 5883, pp. 1647–1651, 2008. View at Publisher · View at Google Scholar · View at PubMed
26. P. J. Turnbaugh, R. E. Ley, M. A. Mahowald, V. Magrini, E. R. Mardis, and J. I. Gordon, “An obesity-associated gut microbiome with increased capacity for energy harvest,” Nature, vol. 444, no. 7122, pp. 1027–1031, 2006. View at Publisher · View at Google Scholar · View at PubMed
27. P. D. Cani, A. M. Neyrinck, F. Fava, et al., “Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia,” Diabetologia, vol. 50, no. 11, pp. 2374–2383, 2007. View at Publisher · View at Google Scholar · View at PubMed
28. D. Raoult, “Obesity pandemics and the modification of digestive bacterial flora,” European Journal of Clinical Microbiology and Infectious Diseases, vol. 27, no. 8, pp. 631–634, 2008. View at Publisher · View at Google Scholar · View at PubMed
29. F. Bäckhed, H. Ding, T. Wang, et al., “The gut microbiota as an environmental factor that regulates fat storage,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 44, pp. 15718–15723, 2004. View at Publisher · View at Google Scholar · View at PubMed
30. H. J. Flint, E. A. Bayer, M. T. Rincon, R. Lamed, and B. A. White, “Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis,” Nature Reviews Microbiology, vol. 6, no. 2, pp. 121–131, 2008. View at Publisher · View at Google Scholar · View at PubMed
31. E. C. M. Leitch, A. W. Walker, S. H. Duncan, G. Holtrop, and H. J. Flint, “Selective colonization of insoluble substrates by human faecal bacteria,” Environmental Microbiology, vol. 9, no. 3, pp. 667–679, 2007. View at Publisher · View at Google Scholar · View at PubMed
32. H. M. Hamer, D. Jonkers, K. Venema, S. Vanhoutvin, F. J. Troost, and R.-J. Brummer, “Review article: the role of butyrate on colonic function,” Alimentary Pharmacology & Therapeutics, vol. 27, no. 2, pp. 104–119, 2008.
33. N. M. Delzenne, P. D. Cani, and A. M. Neyrinck, “Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data,” The Journal of Nutrition, vol. 137, no. 11, pp. 2547S–2551S, 2007.
34. T. M. S. Wolever, P. J. Spadafora, S. C. Cunnane, and P. B. Pencharz, “Propionate inhibits incorporation of colonic [1,2-13C]acetate into plasma lipids in humans,” American Journal of Clinical Nutrition, vol. 61, no. 6, pp. 1241–1247, 1995.
35. H. W. Lopez, M.-A. Levrat-Verny, C. Coudray, et al., “Class 2 resistant starches lower plasma and liver lipids and improve mineral retention in rats,” The Journal of Nutrition, vol. 131, no. 4, pp. 1283–1289, 2001.
36. N. M. Delzenne and N. Kok, “Effects of fructans-type prebiotics on lipid metabolism,” American Journal of Clinical Nutrition, vol. 73, no. 2, supplement, pp. 456S–458S, 2001.
37. S. Sakakibara, T. Yamauchi, Y. Oshima, Y. Tsukamoto, and T. Kadowaki, “Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice,” Biochemical and Biophysical Research Communications, vol. 344, no. 2, pp. 597–604, 2006. View at Publisher · View at Google Scholar · View at PubMed
38. B. S. Samuel, E. E. Hansen, J. K. Manchester, et al., “Genomic and metabolic adaptations of Methanobrevibacter smithii to the human gut,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 25, pp. 10643–10648, 2007. View at Publisher · View at Google Scholar · View at PubMed
39. A. Belenguer, S. H. Duncan, A. G. Calder, et al., “Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut,” Applied and Environmental Microbiology, vol. 72, no. 5, pp. 3593–3599, 2006. View at Publisher · View at Google Scholar · View at PubMed
40. D. J. Morrison, W. G. Mackay, C. A. Edwards, T. Preston, B. Dodson, and L. T. Weaver, “Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate?,” British Journal of Nutrition, vol. 96, no. 3, pp. 570–577, 2006. View at Publisher · View at Google Scholar
41. B. S. Samuel and J. I. Gordon, “A humanized gnotobiotic mouse model of host-archaeal-bacterial mutualism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 26, pp. 10011–10016, 2006. View at Publisher · View at Google Scholar · View at PubMed
42. T. S. Stappenbeck, L. V. Hooper, and J. I. Gordon, “Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 24, pp. 15451–15455, 2002. View at Publisher · View at Google Scholar · View at PubMed
43. L. V. Hooper, M. H. Wong, A. Thelin, L. Hansson, P. G. Falk, and J. I. Gordon, “Molecular analysis of commensal host-microbial relationships in the intestine,” Science, vol. 291, no. 5505, pp. 881–884, 2001. View at Publisher · View at Google Scholar · View at PubMed
44. F. Bäckhed, J. K. Manchester, C. F. Semenkovich, and J. I. Gordon, “Mechanisms underlying the resistance to diet-induced obesity in germ-free mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 3, pp. 979–984, 2007. View at Publisher · View at Google Scholar · View at PubMed
45. J. M. Ridlon, D.-J. Kang, and P. B. Hylemon, “Bile salt biotransformations by human intestinal bacteria,” Journal of Lipid Research, vol. 47, no. 2, pp. 241–259, 2006. View at Publisher · View at Google Scholar · View at PubMed
46. Y. H. Park, J. G. Kim, Y. W. Shin, S. H. Kim, and K. Y. Whang, “Effect of dietary inclusion of Lactobacillus acidophilus ATCC 43121 on cholesterol metabolism in rats,” Journal of Microbiology and Biotechnology, vol. 17, no. 4, pp. 655–662, 2007.
47. F.-P. J. Martin, Y. Wang, N. Sprenger, et al., “Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model,” Molecular Systems Biology, vol. 4, article 157, pp. 1–15, 2008. View at Publisher · View at Google Scholar · View at PubMed
48. E. Norin, “Intestinal cholesterol conversion in adults and elderly from four different European countries,” Annals of Nutrition and Metabolism, vol. 52, pp. 12–14, 2008. View at Publisher · View at Google Scholar · View at PubMed
49. H.-Y. Lee, J.-H. Park, and S.-H. Seok, “Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice,” Biochimica et Biophysica Acta, vol. 1761, no. 7, pp. 736–744, 2006. View at Publisher · View at Google Scholar · View at PubMed
50. B. Bistrian, “Systemic response to inflammation,” Nutrition Reviews, vol. 65, pp. 170–172, 2007. View at Publisher · View at Google Scholar
51. D. M. L. Tsukumo, M. A. Carvalho-Filho, J. B. C. Carvalheira, et al., “Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance,” Diabetes, vol. 56, no. 8, pp. 1986–1998, 2007. View at Publisher · View at Google Scholar · View at PubMed
52. K. Takeda and S. Akira, “Toll-like receptors in innate immunity,” International Immunology, vol. 17, no. 1, pp. 1–14, 2005.
53. T. Werner and D. Haller, “Intestinal epithelial cell signalling and chronic inflammation: from the proteome to specific molecular mechanisms,” Mutation Research, vol. 622, no. 1-2, pp. 42–57, 2007. View at Publisher · View at Google Scholar · View at PubMed
54. L. C. Parker, L. R. Prince, and I. Sabroe, “Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity,” Clinical & Experimental Immunology, vol. 147, no. 2, pp. 199–207, 2007. View at Publisher · View at Google Scholar · View at PubMed
55. D. Kelly, J. I. Campbell, T. P. King, et al., “Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-$\gamma$ and RelA,” Nature Immunology, vol. 5, no. 1, pp. 104–112, 2003. View at Publisher · View at Google Scholar · View at PubMed
56. A. S. Neish, A. T. Gewirtz, H. Zeng, et al., “Prokaryotic regulation of epithelial responses by inhibition of I$\kappa$B-$\alpha$ ubiquitination,” Science, vol. 289, no. 5484, pp. 1560–1563, 2000. View at Publisher · View at Google Scholar
57. J.-M. Otte, E. Cario, and D. K. Podolsky, “Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells,” Gastroenterology, vol. 126, no. 4, pp. 1054–1070, 2004. View at Publisher · View at Google Scholar
58. M. S. Lee and Y. J. Kim, “Signaling pathways downstream of pattern-recognition receptors and their cross talk,” Annual Review of Biochemistry, vol. 76, pp. 447–480, 2007. View at Publisher · View at Google Scholar · View at PubMed
59. J. Pietsch, A. Batra, T. Stroh, et al., “Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation,” Annals of the New York Academy of Sciences, vol. 1072, pp. 407–409, 2006. View at Publisher · View at Google Scholar · View at PubMed
60. A. Batra, J. Pietsch, I. Fedke, et al., “Leptin-dependent Toll-like receptor expression and responsiveness in preadipocytes and adipocytes,” The American Journal of Pathology, vol. 170, no. 6, pp. 1931–1941, 2007. View at Publisher · View at Google Scholar · View at PubMed
61. J. Siebler, P. R. Galle, and M. M. Weber, “The gut-liver-axis: endotoxemia, inflammation, insulin resistance and NASH,” Journal of Hepatology, vol. 48, no. 6, pp. 1032–1034, 2008. View at Publisher · View at Google Scholar · View at PubMed
62. N. M. Delzene and A. M. Neyrik, “Prebiotics and lipid metabolism: review of experimental and human data,” in Handbook of Prebiotics, G. R. Gibson and M. Roberfroid, Eds., pp. 201–218, Taylor & Francis, Philadelphia, Pa, USA, 2008.
63. F. Calcinaro, S. Dionisi, M. Marinaro, et al., “Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse,” Diabetologia, vol. 48, no. 8, pp. 1565–1575, 2005. View at Publisher · View at Google Scholar · View at PubMed
64. C. Bleau, L. Lamontagne, and R. Savard, “New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-$\gamma$ production,” Clinical & Experimental Immunology, vol. 140, no. 3, pp. 427–435, 2005. View at Publisher · View at Google Scholar · View at PubMed
65. M. Naruszewicz, M.-L. Johansson, D. Zapolska-Downar, and H. Bukowska, “Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers,” American Journal of Clinical Nutrition, vol. 76, no. 6, pp. 1249–1255, 2002.
66. S. Mueller, K. Saunier, C. Hanisch, et al., “Differences in fecal microbiota in different European study populations in relation to age, gender, and country: a cross-sectional study,” Applied and Environmental Microbiology, vol. 72, no. 2, pp. 1027–1033, 2006. View at Publisher · View at Google Scholar · View at PubMed