Archetypical histopathology of brain and liver during acute infection with neurotropic strain. MHV-A59: serial coronal sections from MHV-A59-infected mice at day 5 post infection were stained with H & E or immunostained for CD45 (LCA: leukocyte common antigen, marker for inflammatory cells) or microglia/macrophage marker CD11b (OX42). (a) H & E staining shows acute meningitis and inset shows the presence of inflammatory cells positive for LCA. (b) Coronal sections stained for LCA show acute encephalitis in brain section characterized by the formation of perivascular cuffing in high magnification. Inset shows presence of inflammatory infiltrates throughout the parenchyma. (c) The majority of LCA-positive inflammatory cells are stained positive for the macrophage/microglia marker CD11b in MHV-A59-infected brain parenchyma. (d) Liver pathology from the same infected mouse stained with H & E shows lesions throughout the liver section.
