Demyelination and axonal loss in a neurotropic strain of MHV, MHV-A59-infected mouse spinal cord. Serial cross-sections (5 m thick) from MHV-A59-infected mouse spinal cord at day 7 p.i. were stained for myelin with LFB or by Bielchowsky silver impregnation. (a) A large demyelinating plaque observed in MHV-A59-infected mouse spinal cord is shown (arrow indicates demyelinated area). (b) In an adjacent section, the same demyelinating plaque of MHV-A59-infected spinal cord shows loss of axons (arrow indicates area of axonal loss) (adapted from the work of [73]).
