<i>COMT</i> Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence : Figure 1

]><i>COMT</i> Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence : Figure 1

Figure 1: A theoretical model illustrating the interaction effect of a single genotype (i.e., COMT Val158Met polymorphism) and endophenotype (i.e., executive functioning domain deficit) on a behavioral phenotype (i.e., number of sexual partners). Among carriers of the COMT Met/Met and to a lesser extent the Val/Met genotype the association between executive functioning deficit and number of sexual partners is significantly stronger than among carriers of the Val/Val genotype. *; ^**.