Natural History and Factors Associated with Early and Delayed Mortality in HIV-Infected Patients Treated of Tuberculosis under Directly Observed Treatment Short-Course Strategy: A Prospective Cohort Study in India

Table 2

Cox regression analysis of factors associated with death during the first three months of anti-tuberculosis treatment.

	Overall		Males		Females
	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value
Age (years)
<35	1		1		1
>35	1.37 (1.06–1.77)	0.017	1.24 (0.91–1.68)	0.179	1.83 (1.14–2.94)	0.013
Literacy
Yes	1		1		1
No	1.08 (0.82–1.41)	0.593	0.98 (0.72–1.34)	0.917	1.5 (0.75–2.98)	0.248
Homeless
No	1		1		1
Yes	2.6 (1.65–4.08)	<0.001	2.57 (1.34–4.93)	0.004	3.29 (1.69–6.42)	<0.001
Community
ST/SC	1.41 (1.08–1.84)	0.011	1.58 (1.15–2.16)	0.005	1.06 (0.64–1.75)	0.822
OC/BC	1		1		1
CD4+ lymphocyte count*
<100	2.22 (1.4–3.52)	0.001	1.74 (0.99–3.04)	0.053	3.09 (1.35–7.09)	0.008
100–250	1.52 (0.95–2.42)	0.08	1.2 (0.69–2.11)	0.521	2.14 (0.92–4.95)	0.077
>250	1		1		1
Previous ATT
No (category I)	1		1		1
Yes (category II)	1.2 (0.88–1.63)	0.251	1.15 (0.8–1.65)	0.452	1.32 (0.73–2.38)	0.364
Organ involved
Meningitis	1.82 (1.37–2.43)	<0.001	2.02 (1.45–2.83)	<0.001	1.21 (0.67–2.21)	0.526
Disseminated	1.43 (0.87–2.38)	0.162	1.45 (0.82–2.55)	0.197	1.5 (0.46–4.84)	0.5
Others	1		1		1
ART before ATT
No	1		1		1
Yes	1.32 (1.01–1.73)	0.043	1.28 (0.92–1.77)	0.138	1.46 (0.89–2.39)	0.135
Gender
Male	1.12 (0.83–1.5)	0.456
Female	1

AFB: acid fast bacilli; ART: antiretroviral therapy; ATT: anti-tuberculosis treatment; CI: confidence interval; HR: hazard ratio. *cells/mm³.