Clinical Study
Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study
Table 2
Type and site of infection and severity of sepsis by appropriateness of empiric antimicrobial therapy.
| | Infection/sepsis | All patients
() | Inappropriate first dose of antimicrobial therapy
() | Appropriate first dose of antimicrobial therapy
() | Inappropriate 24-hour antimicrobial therapy
() | Appropriate 24-hour antimicrobial therapy
() |
| | Type of infection—no. (%) | | | | | | (i) Community-
acquired* | 63 (27.5) | 10 (14.7) | 53 (32.9) | 9 (14.3) | 54 (85.7) | | (ii) Healthcare associated | 85 (37.1) | 29 (42.6) | 56 (34.8) | 19 (22.3) | 66 (77.6) | | (iii) Hospital-acquired | 81 (35.4) | 29 (42.6) | 52 (32.3) | 30 (37.0)* | 51 (63.0) |
| | Site of infection—no. (%) | | | | | | | (i) Respiratory | 75 (32.8) | 23 (33.8) | 52 (32.3) | | | | (ii) Intra-abdominal | 54 (23.6) | 14 (20.6) | 40 (24.8) | | | | (iii) Genitourinary* | 47 (20.5) | 20 (27.9) | 27 (16.8) | | | | (iv) Primary blood stream | 19 (8.3) | 7 (10.3) | 12 (7.5) | | | | (v) Skin and soft tissue* | 18 (7.9) | 17 (10.6) | 1 (1.5) | | | | (vi) Intravascular catheter | 9 (3.9) | 1 (1.5) | 8 (5.0) | | | | (vii) Surgical site | 3 (1.3) | 2 (2.9) | 1 (0.6) | | | | (viii) Cardiovascular | 2 (0.9) | 0 | 2 (1.2) | | | | (ix) Bone and joint | 2 (0.9) | 0 | 2 (1.2) | | |
| | Severity of sepsis—no. (%) | | | | | | | APACHE II score, unit mean (SD) | 24.7 (6.8) | 24.6 (7.0) | 24.7 (6.8) | | | | APACHE II score 25–30 unit no. (%) | 64 (27.9) | 21 (30.9) | 43 (26.7) | | | | APACHE II score >30 unit no. (%) | 48 (21.0) | 14 (20.6) | 34 (21.1) | | | | (i) Sepsis | 31 (13.5) | 13 (19.1) | 18 (11.2) | | | | (ii) Severe sepsis | 58 (25.3) | 16 (23.5) | 42 (26.1) | | | | (iii) Septic shock* | 140 (61.1) | 39 (57.4) | 101 (62.7) | | |
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