Clinical Study
Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study
Table 3
Type of microorganism isolated from blood by appropriateness of empiric antimicrobial therapy.
| | Type of bacteria | All patients
() | Inappropriate first dose of antimicrobial therapy
() | Appropriate first dose of antimicrobial therapy
() |
| | Gram-positive bacteria—no. (%) | 63 (27.5) | 13 (19.1) | 50 (31.1) | | Streptococcus pneumonia | 2 (0.9) | 0 | 2 (1.2) | | Streptococcus gr. B, C, D, G | 12 (5.2) | 0 | 12 (7.5) | | Alpha-hemolytic Streptococcus | 7 (3.1) | 0 | 7 (4.3) | | MSSA* | 20 (8.7) | 1 (1.5) | 19 (11.8) | | MRSA* | 11 (4.8) | 7 (10.3) | 4 (2.5) | | CNSA | 3 (1.3) | 1 (1.5) | 2 (1.2) | | Enterococcus faecalis | 1 (0.4) | 0 | 1 (0.6) | | Enterococcus faecium
* | 5 (2.2) | 4 (5.9) | 1 (0.6) |
| | Gram-negative bacteria*—no. (%) | 166 (72.5) | 55 (80.9) | 111 (68.9) | | Acinetobacter spp.** | 28 (12.2) | 17 (25.0) | 11 (6.8) | | Escherichia coli | 66 (28.8) | 25 (38.8) | 41 (25.5) | | (i) ESBL-positive** | 28 (12.2) | 24 (35.3) | 4 (2.5) | | Klebsiella pneumoniae
* | 29 (12.7) | 4 (5.9) | 25 (15.5) | | (i) ESBL-positive | 7 (3.1) | 4 (5.9) | 3 (1.9) | | Proteus mirabilis | 5 (2.2) | 1 (1.5) | 4 (2.5) | | (i) ESBL-positive | 1 (0.4) | 0 | 1 (0.6) | | Pseudomonas aeruginosa | 10 (4.4) | 1 (1.5) | 9 (5.6) | | Salmonella spp. | 10 (4.4) | 3 (4.4) | 7 (4.3) | | Other non-fermentative gram-negative bacilli | 9 (3.9) | 3 (4.4) | 6 (3.7) | | Enterobacter spp. | 3 (1.3) | 1 (1.5) | 2 (1.2) | | Other gram-negative bacteria*** | 8 (3.5) | 0 | 8 (5.0) |
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*.
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***Organism (); Vibrio spp. (2), Aeromonas spp. (2), Stenotrophomonas maltophilia (1), Burkholderia pseudomallei (1), Citrobacter koseri (1), Roseomonas spp. (1).
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