Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study
Table 7
Multivariate analysis of factors associated with 28-day and overall mortality.
Factors
Total N (%)
Overall mortality ( value)
OR (95% CI)
28-day mortality ( value)
OR (95% CI)
Inappropriate first dose
68 (29.7)
0.049
2.52 (1.01–6.32)
0.059
2.48 (0.97–6.36)
Inappropriate 24-hour dose
58 (25.3)
0.251
0.61 (0.26–1.42)
0.323
0.65 (0.28–1.53)
Duration from sepsis until first-dose antimicrobial therapy >3 hours
117 (51.1)
0.009
1.80 (1.16–2.80)
0.006
1.94 (1.21–3.10)
Congestive heart failure
50 (21.8)
<0.001
2.07 (1.39–3.10)
<0.001
2.17 (1.43–3.30)
Age > 65 years
111 (48.5)
0.022
1.55 (1.07–2.26)
0.114
1.38 (0.93–2.05)
Platelet < 100,000 per uL
109 (47.6)
0.010
1.67 (1.13–2.46)
0.029
1.55 (1.05–2.30)
Serum albumin < 3.2 g/dL
171 (74.7)
0.016
1.74 (1.11–2.74)
0.030
1.71 (1.05–2.76)
APACHE II score ≥ 25
100 (43.7)
0.011
1.66 (1.13–2.44)
<0.001
2.12 (1.41–3.19)
Sepsis shock
140 (61.1)
0.001
1.93 (1.30–2.87)
0.009
1.75 (1.15–2.65)
Other variables: infection acquisition site (community or nosocomial); source of infection; septic shock; APACHE II scores; major co-morbidities (neutropenia and liver failure); predictive of mortality laboratories (white blood cell less than 4000 per mm3); drug-resistant organism.
