Research Article

Pyoverdine, the Major Siderophore in Pseudomonas aeruginosa, Evades NGAL Recognition

Figure 6

Ferric pyoverdine superimposed on ferric Enterobactin docked into NGAL. The docking of ferric pyoverdine to NGAL is superimposed on ferric enterobactin bound to NGAL. (1) NGAL molecular surface representation with Fe-ENT bound in the hydrophobic calyx where Fe-PVD docking site is buried under the surface. In the surface representation, blue indicates a hydrophobic region, while red indicated a hydrophilic region. Fe-ENT and Fe-PVD are shown as stick figures. (2) NGAL molecular surface representation with 50% transparency. (3) NGAL backbone (fuchsia) with the Fe-PVD surface shown in 50% transparency. This figure was generated using the UCSF Chimera package [25, 26].
843509.fig.006