Review Article

Iatrogenic Cushing Syndrome Secondary to Ritonavir-Epidural Triamcinolone Interaction: An Illustrative Case and Review

Table 2

Summary of other cases.

Reference/author journalCaseHAART regimenInjection (TCA)Clinical presentationHydrocortisone replacementTime to recovery

Yombi et al.
Clin Rheumatol 2008 [5]
54 yo woman3TC/DDI/lopinavir-ritonavir40 mg (knee)IACS
Hypertension
SAI
20 mg daily8 months
56 yo manD4T/AZT/indinavir-ritonavir40 mg (cervical)IACS
SAI
10 mg daily4 months
49 yo woman3TC/DDI/lopinavir-ritonavir40 mg (shoulder)IACS
SAI
None5 months

Ramanathan et al. [6]
CID 2008
35 yo manTenofovir-emtricitabine/lopinavir-ritonavir60 mg and then 80 mg (L spine)IACS
Hypertension
Esophageal reflux
4 months

Danaher et al. [7]
Orthopedics 2009
44 yo manRitonavir based regimen80 mg (hip)HHS-ICU admission
IACS
SAI
UnknownUnknown

Dort et al. [8]
AIDS Research and Therapy 2009
41 yo manTenofovir-emtricitabine, atazanavir-ritonavir80 mg twice (epidural)IACS
Hypertension
AVN hip (at 11 months)
None6 months
42 yo womanTenofovir-emtricitabine, atazanavir-ritonavir40 mg (shoulder)IACS30 mg daily (short)2 months

Levine et al. [9]
J Am Acad Dermatol 2011
41 yo womanLamivudine, tenofovir, atazanavir-ritonavir60 mg IM (topical steroid unresponsive nonspecific dermatitis)IACS
SAI
None6 months

Albert et al. [10]
Am J Med Sciences 2012
58 yo womanTenofovir-emtricitabine, fosamprenavir-ritonavirEpidural dose is not mentionedIACS
SAI
None2 months

Grierson and Harrast [11]
Am Acad PMR 2012
47 yo womanTenofovir-emtricitabine, atazanavir-ritonavir80 mg 3 occasions (epidural L spine)“Lipodystrophy”
DM
Metabolic syndrome
IACS
SAI
20 mg daily (extended taper)“Several months”

Fessler et al. [12]
Pain Physician 2012
42 yo manTenofovir-emtricitabine, atazanavir-ritonavir80 mg (lumbar epidural)Hypertension
Acne (on back)
None3 months
47 yo womanAbacavir, lamivudine, darunavir-ritonavir → changed to abacavir, lamivudine, unboosted fosamprenavir upon dx80 mg 2 occasions (lumbar epidural)
Also used inhaled fluticasone/salmeterol inhaler for asthma for 5 days
Weight gain
Emotional lability
IACS
Hypertension
Oral candidiasis
None10 weeks (improved)

Maviki et al. [13]
Skeletal Radiology 2013
39 yo womanTenofovir-emtricitabine, darunavir-ritonavir40 mg 2 occasions (right L5 nerve root)IACS
Oral candidiasis
SAI
Hydrocortisone “maintenance”8 months
47 yo manTenofovir-emtricitabine, lopinavir-ritonavir80 mg (subacromial, subdeltoid bursa)IACS
Hyperglycemia
Weight gain
SAI
Hydrocortisone “maintenance”6 months

Schwarze-Zander et al. [14]
Infection
2013
35 yo womanTenofovir-emtricitabine, saquinavir-ritonavir → changed to tenofovir-emtricitabine with raltegravir6 times 20 mg weekly (L5-S1 periradicular)IACS
Hypokalemia
SAI
Steroid-induced myopathy
Acute herpes zoster (4 week later)
Hydrocortisone 15 mg/daily-tapered at 8 months
Comment: also needed potassium replacement for hypokalemia
8 months

Hall et al. [15]
Int J STD AIDS
2013
53 yo womanDarunavir-ritonavir
Raltegravir
40 mg (left shoulder)Hyperglycemia (worse than usual for her controlled DM)
Hypertension (worse than prior)
IACS
Anxiety
None
Comment: needed initiation of insulin for DM previously controlled by metformin
3 months

Sadarangani et al.48 yo womanTenofovir-emtricitabine, atazanavir-ritonavir → changed to tenofovir-emtricitabine with raltegravir40 mg triamcinolone epidural injection and 20 mg triamcinolone injection into right trochanteric bursaSevere esophagitis (erosive, as well as candida and HSV esophagitis)
IACS
Relative SAI
Mood changes-anxiety
Weight gain
None
Comment: needed course of fluconazole and valacyclovir as well as extended course therapy with proton pump inhibitor for esophagitis
3-4 months

HHS: hyperglycemic hyperosmolar state,
3TC: lamivudine,
DDI: didanosine,
D4T: stavudine,
AZT: zidovudine, and
AVN: avascular necrosis.