Adding Streptomycin to an Intensified Regimen for Tuberculous Meningitis Improves Survival in HIV-Infected Patients

Table 2

Univariate and multivariate analyses of mortality using Cox proportional hazard models.

	HR (95% CI)	aHR (95% CI)
Intensified versus standard ATT	0.90 (0.62–1.32)	1.14 (0.74–1.76)
Intensified + STM versus standard ATT	0.47 (0.24–0.93)	0.20 (0.09–0.46)
Female	0.87 (0.58–1.31)	0.79 (0.52–1.20)
On ART	0.60 (0.39–0.91)	0.64 (0.40–1.02)
Previous ATT	1.02 (0.66–1.59)	3.23 (1.68–6.24)
Age (years)	1.00 (0.98–1.02)	1.00 (0.98–1.01)
Albumin (g/dL)	0.66 (0.53–0.83)	0.74 (0.58–0.95)

value <0.05; aHR, adjusted hazard ratio; ART, antiretroviral therapy; ATT, antituberculosis therapy; HR, hazard ratio; STM, streptomycin. Adjusted hazard ratios are also adjusted for CD4 cell counts using restricted cubic splines (see Figure 2).