Research Article

Preexisting Atrial Fibrillation Associated with Higher Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bloodstream Infections: Analysis of the National Inpatient Sample

Table 1

Study population patient characteristics stratified by MRSA-BSI with and without AF.

CharacteristicsMRSA-BSI with AF (N, %)MRSA-BSI without AF (N, %) value

(Total N = 52,805)43,505 (82%)9,300 (18%)
Mean age, in years (IQR)75.3 (IQR = 74.8–75.9)59.6 (IQR = 59.2–60.03)<0.0001
 18–44 years870 (2%)2,074 (22.3%)
 45–64 years6,0004 (13.8%)3,143 (33.8%)
 ≥65 years36,631 (84.2%)4,083 (43.9%)
Race<0.0001
 White36,109 (83%)6,445 (69.2%)
 Black3,437 (7.9%)1,404 (15.1%)
 Hispanic2,045 (4.7%)911 (9.8%)
 Others1,914 (4.4%)549 (5.9%)
 Male28,409 (65.3%)5,087 (54.7%)<0.0001
 Female15,096 (34.7%)4213 (45.3%)<0.0001
Insurance<0.0001
 Medicare35,761 (82.2%)4808 (51.7%)
 Medicaid2,001 (4.6%)1,832 (19.7%)
 Private insurance including HMO4742 (10.9%)1972 (21.2%)
 Other/self-pay/uninsured1,001 (2.3%)707 (7.4%)
Number of hospital beds0.01
 Small10,006 (23%)1981 (21.3%)
 Medium12,442 (28.4%)2,437 (26.2%)
 Large21,153 (48.6%)4,883 (52.5%)
Hospital teaching status0.001
 Nonteaching hospital15,488 (35.6%)2,892 (31.1%)
 Teaching hospital28,017 (64.4%)6,408 (68.9%)
Hospital region0.21
 Northeast10,403 (23.9%)2,111 (22.7%)
 Midwest10,398 (23.9%)2,083 (22.4%)
 South15,096 (34.7%)3,404 (36.6%)
 West7,613 (17.5%)1,702 (18.3%)
Median annual income expected for patient’s ZIP code, USD<0.0001
 $1—$45,99910,354 (23.8%)2,781 (29.9%)
 $46,000—$58,99911,833 (27.2%)2,585 (27.8%)
 $59,000—$78,99910,963 (25.2%)2,176 (23.4%)
 ≥$79,00010,354 (23.8%)1,758 (18.9%)
Comorbidities
 Coronary artery disease18,185 (41.8%)1,683 (18.1%)<0.0001
 Congestive heart failure19,490 (44.8%)1,097 (11.8%)<0.0001
 Previous MI8,788 (20.2%)781 (8.5%)<0.0001
 Chronic kidney disease16,967 (39%)2,027 (21.8%)<0.0001
 Hypertension15,227 (35%)3,432 (36.9%)0.1
 Previous stroke261 (0.6%)28 (0.3%)0.03
 Dyslipidemia21,970 (50.5%)2,874 (30.9%)<0.0001
 Nicotine use14,912 (34%)3,581 (38.5%)0.0003
 Chronic liver disease2,784 (6.4%)809 (8.7%)0.0009
 Peripheral vascular disease2,5667 (5.9%)270 (2.9%)<0.0001
 Obesity7,526 (17.3%)1,228 (13.2%)<0.0001
 Anemia16,184 (37.2%)3,339 (35.9%)0.27
 Pulmonary hypertension3,785 (8.7%)233 (2.5%)<0.0001
 Previous CABG5,569 (12.8%)428 (4.6%)<0.0001
 Previous pacemaker5,960 (13.7%)233 (2.5%)<0.0001
 Previous defibrillator3,306 (7.6%)140 (1.5%)<0.0001
 Uncomplicated diabetes17,881 (41.1%)2,957 (31.8%)<0.0001
 Complicated diabetes11,442 (26.3%)1,609 (17.3%)<0.0001
 Previous PCI479 (1.1%)56 (0.6%)0.006
 Carotid artery disease609 (1.4%)52 (0.56%)<0.0001
 Electrolyte abnormalities13,443 (30.9%)2,660 (28.6%)0.047
 Dialysis dependent3,485 (8.01%)716 (7.7%)0.64
 COPD7,526 (17.3%)1,014 (10.9%)<0.0001
 Oxygen use1,740 (4%)177 (1.9%)<0.0001
 Protein energy malnutrition3,654 (8.4%)707 (7.6%)0.24
 Frailty130 (0.3%)74 (0.08%)0.007
 Dementia5,308 (12.2%)614 (6.6%)<0.0001
 Long term anticoagulation use16,967 (39%)521 (5.6%)<0.0001
 Aspirin use6,047 (13.9%)1,730 (18.6%)<0.0001
Charlson comorbidity index<0.0001
 0–224,624 (56.6%)6,538 (70.3%)
 3–53,179 (7.2%)1,051 (11.3%)
 ≥615,749 (36.2%)1,711 (18.4%)