A Time Course for Susceptibility to Staphylococcus aureus Respiratory Infection during Influenza in a Swine Model
Figure 4
Microscopic lesions in the lung of infected pigs. (a) Sham-infected, (b) MRSA only, (c) SIV 3 days postinfection, (d) SIV 4 days postinfection, (e) SIV 5 days postinfection, (f) SIV 6 days postinfection, (g) Dual D3, (h) Dual D4, (i) Dual D5, and (j) Dual D6. Sham-infected and MRSA only groups had no microscopic evidence of pneumonia (a-b). SIV alone and Dual groups exhibited regionally extensive interstitial or bronchointerstitial pneumonia at all time points (c–j). Affected bronchioles and alveolar spaces were filled with lymphocytes, plasma cells, and fewer neutrophils. Alveolar septa were expanded by similar inflammatory cells. All bars represent 100 um.
