3D Molecular Modelling Study of the H7N9 RNA-Dependent RNA Polymerase as an Emerging Pharmacological Target
Figure 3
The 3D spatial conformation of the H7N9 RdRp oligonucleotide tunnel. (a) The shape of the H7N9 RdRp oligonucleotide tunnel. The ssRNA fragment is shown in purple color. (b) The residues that comprise the active sites of the H7N9 RdRp oligonucleotide tunnel. The two “roadblocking” serine and isoleucine residues are indicated by the large black arrows. Their role is to prevent the oligonucleotide to reversely slide out in the wrong direction.
