Activities of neutralizing antibodies to influenza virus induced by B cell stimulation. Influenza virus stimulates B cell responses through a sequential process of activation, proliferation, isotype-switching, affinity maturation and selection of antibodies, and memory. The major activities of neutralizing antibody types to viral HA are shown in the inset box [13]. HA-specific antibodies are highly functional and prevent virus infection resulting in less cells being infected in vivo.
