Table 1: Clinical and mycological features of cryptococcal meningitis.

Signs and symptomsHIV-positive patients, 
*
HIV-positive patients, Africa,  
HIV-negative patients,  
#
Total,  
HIV-positive children,

Headache839/1014 (82.7)2646/3324 (79.6)292/500 (58.4)3777/4838 (78.1)40/60 (66.7)
Fever812/1080 (75.2)1914/3322 (57.6)352/500 (70.4)3078/4902 (62.8)31/60 (51.7)
Cough267/994 (26.9)16/67 (23.9)78/324 (24.1)361/1385 (26.1)NR
Dyspnea119/872 (13.6)NR56/292 (19.2)175/1164 (15.1)7/47 (14.9)
Meningismus or neck stiffness342/889 (38.5)2240/3330 (67.3)181/453 (39.9)2763/4672 (59.1)14/56 (25)
Visual changes171/593 (28.8)NR2/16 (12.5)173/609 (28.4)1/40 (2.5)
Altered mental status203/1080 (18.8)937/3347 (27.9)236/451 (52.3)1378/4878 (28.2)15/60 (25)
Seizures28/456 (6.1)304/3323 (9.1)48/458 (10.5)380/4237 (8.9)9/60 (15)
Skin lesions19/321 (5.9)NR6/32 (18.7)25/343 (7.3)1/60 (1.6)
AIDS-defining illness540/1101 (49)484/568 (85.2)1024/1669 (61.3)8/30 (27)

Mycology

Positive CSF culture1200/1274 (94.2)3030/3364 (90.1)381/464 (82.1)4611/5102 (90.4)97/110 (88.2)
Positive CSF antigen489/530 (92.3)1693/1757 (96.3)432/447 (96.6)2614/2734 (95.6)38/62 (61.3)
Positive India ink886/1132 (78.3)3075/3360 (91.5)269/456 (58.9)4230/4948 (85.5)44/50 (88)
Positive serum antigen292/305 (95.7)NR121/141 (85. 8)413/446 (92.6)10/34 (29.4)
Positive blood cultures645/1369 (47.1)371/524 (70.8)106/395 (26.8)1122/3991 (28.1)22/43 (51.2)

NR: not reported.
References [7, 20, 7280].
References [28, 5557, 8186].
#References [20, 7981, 8791].
References [100103, 105].