Table 3: Clinical manifestations of paradoxical and ART-associated cryptococcosis.

Clinical syndromeReferences

Paradoxical cryptococcal IRIS

Meningitis [13, 130, 135, 136, 138140, 145, 149, 150, 154158]
Other CNS-IRIS manifestations
 (i) Intracranial space-occupying lesion/s[136, 146, 159, 160]
 (ii) Meningoradiculitis[163]
 (iii) Hearing loss[161]
Lymphadenopathy[135, 136, 145, 147, 151, 158, 164]
Cutaneous and/or soft-tissue lesions[130, 165, 176]
Pneumonia or pulmonary nodules[130, 136, 145]

ART-associated cryptococcal IRIS

Unmasking meningitis[129, 135]
Lymphadenopathy[166, 169]
Cutaneous and/or soft-tissue lesions[168, 170]
Pneumonia[167]