Research Article

Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography

Table 3

Precision results of 2-CMPB and 2-BMPB.

2-CMPB2-BMPB
S. no.System precision
(area ratio)
Method precision (µg/g)Ruggedness (µg/g)System precision (area ratio)Method precision (µg/g)

11.3185.284.820.7854.96
21.3315.314.870.7894.46
31.3095.285.090.7794.63
41.3345.305.080.7624.38
51.3125.244.950.7784.67
61.3065.254.960.7834.40

Avg.1.3185.284.960.7794.58
SD0.010.030.110.010.220
% RSD0.90.52.21.24.8