Table 9: Results of determination of IMH in tablet and statistical comparison with the reference method.

Formulation brand nameNominal amount, mg/tab% IMH found* ± SD
Reference methodProposed method t-valueF-value

Imipraminea25 mg99.38 ± 0.3099.95 ± 0.152.0074.064
Depranilb25 mg99.55 ± 0.22100.04 ± 0.132.1742.723

Marketed by aSun and bLa Pharma.
*Mean value of five determinations.
Tabulated t-value at 95% confidence level is 2.78; tabulated F-value at 95% confidence level is 6.39.