Table 1: Ionotropic ACh and GABA receptors. Nomenclature and related monogenic epilepsies.

Receptor Subunit Gene Epilepsy

Muscle nAChR
CHRNA1
CHRNB1
CHRNG
CHRND
CHRNE

Neuronal nAChR
CHRNA2 Sleep-related epilepsy
CHRNA3
CHRNA4 ADNFLE
CHRNA5–CHRNA10
CHRNB2 ADNFLE
CHRNB3
CHRNB4

GABA receptors GABRA1 JME, CAE
GABRA2–GABRA6
GABRB1
GABRB2
GABRB3 CAE
GABRG1
GABRG2FS, CAE, DS, GEFS+
GABRG3
GABRD FS, GEFS+
GABRE
GABRQ
GABRR1–GABRR3
GABRP

Legend. ADNFLE: autosomal dominant nocturnal frontal lobe epilepsy; CAE: childhood absence epilepsy; DS: Dravet syndrome; GEFS+: generalized epilepsy with febrile seizures plus; JME: juvenile myoclonic epilepsy. For reference about GABA receptors and epilepsy, see [48].