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ISRN Biochemistry
Volume 2012 (2012), Article ID 506160, 36 pages
http://dx.doi.org/10.5402/2012/506160
Review Article

Ganglioside Biochemistry

Program Unit Membrane Biology & Lipid Biochemistry, LiMES, University of Bonn, Gerhard-Domagk Straße 1, 53121 Bonn, Germany

Received 18 September 2012; Accepted 9 October 2012

Academic Editors: H. Itoh and B. Penke

Copyright © 2012 Thomas Kolter. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence, and metabolism. Key functional, biochemical, and pathobiochemical aspects are summarized.