Table 3: Regulators involved in regulating glutamate-dependent acid resistance.

Protein DescriptorFunction in acid resistance

RpoDσ 70Transcription of gadA/BC
RpoSσ 38Transcription of gadX
EvgAS Two-component signal transduction Activates ydeO and gadE transcription
YdeOAraC-like regulatorActivates gadE transcription
GadELuxR-related activatorRequired for acid resistance, binds to Gad box, activates transcription of gadA/BC, autoactivates gadE, and represses ydeO
GadXAraC-like regulatorActivates gadE, coactivates gadA/BC, and represses gadW
GadWAraC-like regulatorInhibits RpoS production, activates gadE, can coactivate gadA/BC at pH 8
CrpcAMP receptor proteinInhibits RpoS production
TrmEEra-like GTPaseActivates gadE mRNA production and stimulates translation of gadA and gadB mRNA
HNSHistone-like proteinNegative regulator
TorRResponse regulator of TMAO reductaseNegative regulator of gadE

[333].