913273.fig.005a
(a)
913273.fig.005b
(b)
Figure 5: Knock-in and transgenic approaches of iChIP. (a) Knocking-in of LexA BE into the endogenous locus or (b) random integration of transgenes retaining LexA BE can be used for iChIP. Zinc-finger nucleases (ZFN) and TALEN technology make gene targeting much easier in cultured cell lines.