About this Journal Submit a Manuscript Table of Contents
ISRN Biochemistry
Volume 2014 (2014), Article ID 843478, 11 pages
http://dx.doi.org/10.1155/2014/843478
Review Article

Synthetic Melatoninergic Ligands: Achievements and Prospects

1Department of Biology, Tver State Medical Academy, 4 Sovetskaya Street, Tver 170100, Russia
2Department of Biochemistry, Tver State Medical Academy, 4 Sovetskaya Street, Tver 170100, Russia
3Research Center, Tver State Medical Academy, 4 Sovetskaya Street, Tver 170100, Russia

Received 5 November 2013; Accepted 16 January 2014; Published 23 February 2014

Academic Editors: A. Azem and Z. Debyser

Copyright © 2014 N. V. Kostiuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pineal hormone melatonin is widely used in the treatment of disorders of circadian rhythms. The presence of melatonin receptors in various animal tissues motivates the use of this hormone in some other diseases. For this reason, in recent years investigators continued the search for synthetic analogues of melatonin which are metabolically stable and selective to receptors. This review includes recent information about the most famous melatonin analogues, their structure, properties, and physiological features of the interaction with melatonin receptors.