Review Article

Challenges in Enzymatic Route of Mannitol Production

Figure 5

Mechanism of action of mtlADR operon. The transcriptional activator MtlR, which in the presence of mannitol produces derepression of the mtlADR operon, but when glucose is present in the medium, this operon is a target of catabolite repression (through CRP), independent of MtlR. MtlA takes up exogenous mannitol, releasing the phosphate ester, mannitol-1-P, into the cell cytoplasm, but it is not clear which of the two metabolites is the inducer of MtlR http://biocyc.org/ECOLI/NEW-IMAGE?type=OPERON&object=TU00193.
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