Review Article

Risks and Benefits of Thrombolytic, Antiplatelet, and Anticoagulant Therapies for ST Segment Elevation Myocardial Infarction: Systematic Review

Table 2

Bleeding criteria found in studies and number of arms that consider each of them.

NumberCriteriaNumber (%) of arms

1TIMI [72] criteria28 (21.1%)
2GUSTO [60] criteria24 (18.0%)
3Intraocular, retroperitoneal bleeding, transfusion or drop of 50 g/L Hb2 (1.5%)
4Fatal bleeding or bleeding requiring transfusion2 (1.5%)
5GUSTO [60] criteria, excluding hemorrhagic stroke11 (8.3%)
6Fatal bleeding, transfusion of 2 U, drop of 3 g/dL Hb, retroperitoneal, intracranial, ocular or requiring intervention2 (1.5%)
7Need for any transfusion25 (18.8%)
8Hemorrhagic stroke or transfusion of 2 U2 (1.5%)
9Fatal or life threatening bleeding, requiring intervention, prolonged hospitalization, with significant systemic dysfunction4 (3.0%)
10Transfusion of at least 2 U, fatal or intracranial bleeding2 (1.5%)
11Fall in Hb of at least 2 mmol/L, transfusion of 2 U, need for intervention or intracranial bleeding2 (1.5%)
12Transfusion or bleeding excluding puncture site, subcutaneous, hematuria or any drop in Hb described as not serious 2 (1.5%)
13Severe bleeding of the gastrointestinal tract, resulting in shock or transfusion, critical bleeding and hemorrhagic stroke2 (1.5%)
14Nonminor transfusion and bleeding (except puncture site bleeding, streaks of blood in feces and vomit, epistaxis, etc.)3 (2.3%)
15Transfusion of at least 2 U8 (6.0%)
16Hematemesis, melena, hematuria, and severe hemoptysis2 (1.5%)
17Hemorrhagic stroke, hematemesis, severe hematuria, prolonged bleeding, and large hematoma at puncture site2 (1.5%)
18Criteria: gastrointestinal and retroperitoneal bleeding, hemorrhagic stroke4 (3.0%)
19Hemorrhagic stroke6 (4.5%)

Hb: hemoglobin; U: international unit of red blood cells—300 mL; CVA: cerebrovascular accident/stroke.