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ISRN Cell Biology
Volume 2012 (2012), Article ID 597876, 7 pages
http://dx.doi.org/10.5402/2012/597876
Review Article

Focus on ADF/Cofilin: Beyond Actin Cytoskeletal Regulation

Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan

Received 8 November 2011; Accepted 8 December 2011

Academic Editors: V. M. Golubovskaya and A. A. Minin

Copyright © 2012 Cheng-Han Tsai and Yi-Jang Lee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Actin depolymerizing factor (ADF)/cofilin, an actin-binding protein ubiquitously expressed in a variety of organisms, is required for regulation of actin dynamics. The activity of ADF/cofilin is dependent on serine 3 phosphorylation by LIM kinase (LIMK), which is regulated by the Rho small GTPase signaling pathway. ADF/cofilin is strongly associated with several important cell biological functions, including cell cycle, morphological maintenance, and locomotion. These functions affect several biological events, including embryogenesis, oncology, nephropathy, and neurodegenerations. Here, we focus on the biochemical and pathophysiological role of ADF/cofilin in mammals.