Table 1: Oxidative disturbances found in SAMP8.

TargetModificationReferences

Protein carbonylationIncreased[2225]
Lipid peroxidationIncreased[22, 24, 2628]
Nucleic acid oxidationIncreased[25, 29]
Mn SODDecreased activity[30]
Glutathione reductaseNot modified or decreased activity [22, 31]
CatalaseNot modified or decreased activity[22, 31]
Glutamine synthetaseDecreased activity[24]
NO synthaseIncreased activity[3234]
Accumulation of 8-oxoguanineIncreased[35]