Table 2: Histopathological and cellular markers of AD and aging found in SAMP8.

TargetModificationReferences

Tau proteinIncreased levels and phosphorylation[22, 55, 56]
Tau kinasesIncreased levels or activity in Cdk5/p25 and GSK3 [22, 58, 59]
Receptor for advanced glycation end product (RAGE)Increased[75]
APP proteinIncreased[6365, 80, 85, 86]
B-amyloidAmyloid content increased and aggregates[26, 61, 62, 69, 70, 74, 87]
SecretasesADAM-10 and PS1[65, 80, 88]
BBHDisrupted[72, 73, 89]