Table 3: Molecular and cellular pathways altered in SAMP8.

Pathway/protein targetModificationReference

Sirtuin 1Decreased[20, 58, 97]
Autophagic processReduced[117119]
Cathepsin systemInactivated[117]
AMPKNot determined
mTORNot determined
mtDNA damageIncreased[125]
Mitochondrial electron chainDiminished efficiency[20, 21, 29, 126, 127]
Fusion/fission proteinsNot determined
Mitochondrial fatty acid oxidationAltered[128]