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Figure 8: Quarantine control of mitochondrial transportation by PINK1-Parkin signaling. Mitochondria are transported along the microtubule network through the Miro-Milton-KHC complex (1). In neurons, the transportation of healthy mitochondria to the nerve terminal ensures a stable energy supply for a variety of synaptic activities. PINK1 is activated in mitochondria with reduced Δψm and recruits Parkin, which results in Miro degradation; thus, damaged mitochondria are selectively removed from the mitochondrial transport machinery (2). These mitochondria may be further eliminated by PINK1-Parkin-mediated mitophagy.