Review Article
Integrin Signaling as a Cancer Drug Target
Table 1
Transgenic mouse models
1 and
v integrins.
| Model | Cancer type | Effect on tumor growth | Effect on metastasis | Reference |
| β1fl/fl; MMTV-Cre; PyMT | Breast cancer | Impaired initiation; reduced growth | Not studied | [112] | β1fl/fl; MMTV-Cre; ErbB2 | Breast cancer | Delayed initiation; reduced growth; increased apoptosis; reduced angiogenesis | Reduced lung metastasis | [113] | α2−/−; K14-HPV16 | Human papilloma virus-induced squamous carcinoma | Reduced growth; role for tumor cell integrin confirmed after orthotopic transplantation | Decreased progression from papilloma to dysplasia but no effect on subsequent progression to carcinoma | [114] | β1fl/fl; A RR2PBi-Cre; TRAMPtg/+ | Prostate cancer | Increased proliferation; decreased differentiation | Enhanced progression to poorly differentiated carcinoma | [110] | α2−/−; MMTV-c-ErbB2/Neu | Breast cancer | Delayed onset; no effect on tumor growth; no effect on apoptosis; no effect on proliferation | Increased intravasation; increased metastasis | [111] | β1fl/fl; RCre; RIP1Tag2 | Pancreatic β cell carcinoma (insulinomas) | Increased senescence; decreased proliferation | Blocked tumor formation and metastasis after transplantation | [115] | Rag2KO; 3KO; 5KO; xenografted WT tumor cells | Melanoma and lung carcinoma xenografts | Increased tumor angiogenesis; increased tumor growth | Not studied | [116] | Rag2KO; 3KO; 5KO; wild type or KO bone marrow transplantations; xenografted WT tumor cells | Melanoma and colon carcinoma xenografts | Increased tumor angiogenesis; increased tumor growth; reduced macrophage infiltration | Not studied | [77] |
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