Table 2: Transgenic mouse models: FAK.

ModelCancer typeEffect on tumor growthEffect on metastasisReference

FAKfl/fl; MMTV-Cre; PyMTBreast cancerDelayed initiation; decreased growthDecreased lung metastasis[117]
FAKfl/fl; MMTV-Cre; PyMTBreast cancerReduced tumor cell proliferationBlocked progression from hyperplasia to carcinoma; blocked metastasis[118]
FAKfl/fl; MMTV-Cre; PyMTBreast cancerReduced initiation; reduced proliferation; reduced cancer stem/progenitor cell populationNot studied[119]
FAKfl/fl; MMTV-Cre; PyMTBreast cancerReduced initiation; reduced proliferation; increased apoptosis Decreased progression from hyperplasia to carcinoma[120]
FAKfl/fl; K14-CreERT2; two-stage chemical carcinogenesis protocolSkin cancerReduced initiation; reduced growth; increased apoptosisReduced progression from papilloma to squamous cell carcinoma [121]