Table 1: Factors used during robustness testing applied to LC analysis of paliperidone in extended-release OROS tablets.

ConditionReferenceVariation

pH of aqueous solvent3.83.6; 4.0
Concentration of organic solvent (%)30.028.0; 32.0
Flow rate (mL min−1)1.00.8; 1.2
Column supplierShim-pack C18, 25 cmODS-Hypersil, 25 cm