Table 2
(a) Mixed modeling comparing mean OTM per week from baseline to week 8 for weekly aligner versus biweekly control groups

GroupMean/Wk ± SDP value

Weekly aligner Biweekly control 0 . 1 4 ± 0 . 1 1 0.812
0 . 1 4 ± 0 . 1 5

(b) Mixed modeling comparing the mean magnitude of OTM per week expressed during each two-week prescription cycle

GroupIntervalMean/Wk ± SDP value

Weekly alignerWeek 1-2 0 . 1 5 ± 0 . 1 1 0.176
Week 3-4 0 . 1 0 ± 0 . 0 9
Week 5-6 0 . 1 5 ± 0 . 1 1
Week 7-8 0 . 1 6 ± 0 . 1 3

Biweekly controlWeek 1-2 0 . 1 2 ± 0 . 1 1 0.297
Week 3-4 0 . 1 3 ± 0 . 1 3
Week 5-6 0 . 1 3 ± 0 . 1 7
Week 7-8 0 . 1 6 ± 0 . 1 9

(c) Mixed modeling comparing OTM during the first week versus second week for the weekly aligner and biweekly control groups, both separately and combined

GroupIntervalMean/Wk ± SDP value

Weekly aligner1st week 0 . 2 1 ± 0 . 0 9 <0.0001
2nd week 0 . 0 7 ± 0 . 0 8
Biweekly control1st week 0 . 2 3 ± 0 . 1 3 <0.0001
2nd week 0 . 0 4 ± 0 . 1 1

Total1st week 0 . 2 2 ± 0 . 1 2 <0.0001
2nd week 0 . 0 5 ± 0 . 1 0