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ISRN Dermatology
Volume 2012 (2012), Article ID 351842, 3 pages
http://dx.doi.org/10.5402/2012/351842
Research Article

Susceptibility of Dermatophytes to Thiabendazole Using CLSI Broth Macrodilution

1Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, 66450 San Nicolás de los Garza, NL, Mexico
2Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero y Dr. E. A. Pequeño s/n, Colonia Mitras Centro, 64460 Monterrey, NL, México, Mexico

Received 12 July 2012; Accepted 15 August 2012

Academic Editors: B. Amichai and C. R. Daniel

Copyright © 2012 Efrén Robledo-Leal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate in vitro antifungal activity of thiabendazole against strains of dermatophytes using a reference method for filamentous fungi. Materials and Methods. Dermatophytes’ susceptibility to thiabendazole (TBZ) and fluconazole (FCZ) was evaluated using macrodilution method of protocol M38-A2 of the Clinical and Laboratory Standards Institute (CLSI). Results. MIC ranges of TBZ for all strains were narrower and/or smaller than those of FCZ. TBZ showed a significantly greater potency than FCZ ( 𝑃 = 0 . 0 5 ) against all isolates. Discussion. Although there have been approaches to evaluate the antifungal activity of TBZ in human mycoses, no tests had been made with a standardized protocol. Susceptibility data resulted from this study shows that although TBZ is not a particularly strong inhibitor of dermatophytes, it displays a stable and constant effect against all isolates tested. Conclusion. Results show that TBZ is more effective against strains of dermatophytes than FCZ. We acknowledge the antifungal effect of TBZ against dermatophyte isolates.