Table 5: Cytokine expression in experimental EBA.

CytokineSerum concentrationCutaneous expressionFunctional relevanceReference

TNF- Proinflammatory (very moderate)Unpublished
MIP-1 noneUnpublished
GM-CSFProinflammatory (strong)[128]
G-CSFnd
IL-1 Proinflammatory[123]
IL-1 Proinflammatory[123]
IL-2Below detection limitnd
IL-3nd
IL-4ndnd
IL-5ndnd
IL-6Anti-inflammatory[123]
IL-9ndnd
IL-10ndnd
IL-12ndnd
IL-13ndnd
IL-17ndnd
IL-24ndnd
Eotaxinndnd
RANTESndnd
IFN- ndnd
MCP-1ndnd
CXCL1 and CXCL2Proinflammatory[127]
CXCL3ndnd
CXCL5ndnd

Expression data is obtained from Samavedam et al. and from Kasperkiewicz et al. [123, 124]. Functional relevance was evaluated in the indicated publications. “↑”; “—” indicates statistically not significant difference in expression; “nd”: not done.