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ISRN Endocrinology
Volume 2012 (2012), Article ID 507462, 4 pages
http://dx.doi.org/10.5402/2012/507462
Research Article

Hypoglycemic Effect of Laminaria japonica Polysaccharide in a Type 2 Diabetes Mellitus Mouse Model

1Affiliated Hospital, Medical College Qingdao University, Shandong, Qingdao 266003, China
2Institute of Oceanology, Chinese Academy of Sciences, Shandong, Qingdao 266071, China

Received 5 September 2012; Accepted 8 October 2012

Academic Editors: C. Bizzarri and B. Kim

Copyright © 2012 Xiaodan Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim is to investigate the hypoglycemic effect of Laminaria japonica polysaccharides (LJPS) on type 2 diabetes mellitus (T2DM) mice model. 60 healthy male mice have been used in the experiment. T2DM animal mode was prepared by high fatty forage feeding and intraperitoneal injection with alloxan. Diabetic mice were orally supplied with LJPS. Then their blood was collected for various biomedical measurements of fasting blood glucose (FBG), serum insulin, and amylin. Treatment with LJPS significantly reduced fasting blood glucose ( ) and increased the levels of insulin and amylin in serum ( ). Overall, the study presented that LJPS can reverse several components of T2DM. Therefore, LJPS may become a new oral candidate medicine for the treatment of diabetes.