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ISRN Endocrinology
Volume 2012 (2012), Article ID 768159, 13 pages
http://dx.doi.org/10.5402/2012/768159
Review Article

Mass Spectrometry for Diabetic Nephropathy Monitoring: New Effective Tools for Physicians

1Department of Medicine, University of Padova, Via Giustiniani 2, 35137 Padova, Italy
2Istituto di Scienze e Tecnologie Molecolari, Consiglio Nazionale delle Ricerche, Corso Stati Uniti 4, 35127 Padova, Italy

Received 23 December 2011; Accepted 22 January 2012

Academic Editor: C. Bartsch

Copyright © 2012 Annunziata Lapolla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The main aim of diabetic nephropathy monitoring is to identify molecular markers, that is, to find changes occurring at metabolome and proteome levels indicative of the disease’s development. The mass spectrometry methods available today have been successfully applied to this field. This paper provides a short description of the basic aspects of the mass spectrometric methods used for diabetic nephropathy monitoring, reporting and discussing the results obtained using different approaches.