About this Journal Submit a Manuscript Table of Contents
ISRN Endocrinology
Volume 2012 (2012), Article ID 965243, 6 pages
Research Article

Urinary Bisphenol A Levels and Measures of Obesity: Results from the National Health and Nutrition Examination Survey 2003–2008

1Department of Community Medicine, West Virginia University School of Medicine, Robert C. Byrd Health Sciences Center, 1 Medical Center Drive, P.O. Box 9190, Morgantown, WV 26505-9190, USA
2Singapore Eye Research Institute, Singapore 168751
3Department of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore 169857

Received 27 April 2012; Accepted 28 May 2012

Academic Editors: Y. Combarnous, V. A. Lux-Lantos, and J. Vrbikova

Copyright © 2012 Anoop Shankar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bisphenol A (BPA) is a widely used chemical. We examined the association between urinary BPA levels and obesity in the National Health and Nutritional Examination Survey (NHANES) 2003–2008. The main outcome of interest was obesity defined as (1) body mass index (BMI) ≥ 30 Kg/m2 and (2) waist circumference (WC) ≥ 102 cm in men and ≥ 88 cm in women. Urinary BPA levels were examined in quartiles. Overall, we observed a positive association between increasing levels of urinary BPA and both measures of obesity, independent of potential confounding factors including, smoking, alcohol consumption, and serum cholesterol levels. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio (95% confidence interval) associated with quartile 4 for BMI-based obesity was 1.69 (1.30–2.20); 𝑃 -trend < 0.0001 and for WC-based obesity was 1.59 (1.21–2.09); 𝑃 -trend = 0.0009. This association between BPA and both measures of obesity was consistently present across gender and race-ethnic groups (all 𝑃 -trend < 0.05). Elevated levels of urinary BPA are associated with measures of obesity independent of traditional risk factors. This association is consistently present across gender and race-ethnic groups. Future prospective studies are needed to confirm or disprove this finding.