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ISRN Gastroenterology
Volume 2012 (2012), Article ID 391631, 11 pages
http://dx.doi.org/10.5402/2012/391631
Review Article

Current Trends in the Management of Gastroesophageal Reflux Disease: A Review

Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital Ituku/Ozalla, PMB, Enugu 01129, Nigeria

Received 28 April 2012; Accepted 28 May 2012

Academic Editors: P. Correa and C.-T. Shun

Copyright © 2012 Sylvester Chuks Nwokediuko. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Vakil, S. V. van Zanten, P. Kahrilas et al., “The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus,” American Journal of Gastroenterology, vol. 101, no. 8, pp. 1900–1943, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. N. J. Shaheen, R. A. Hansen, D. R. Morgan et al., “The burden of gastrointestinal and liver diseases, 2006,” American Journal of Gastroenterology, vol. 101, no. 9, pp. 2128–2138, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. P. Wahlqvist, M. C. Reilly, and A. Barkun, “Systematic review: the impact of gastro-oesophageal reflux disease on work productivity,” Alimentary Pharmacology and Therapeutics, vol. 24, no. 2, pp. 259–272, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Dent, H. B. El-Serag, M. A. Wallander, and S. Johansson, “Epidemiology of gastro-oesophageal reflux disease: a systematic review,” Gut, vol. 54, no. 5, pp. 710–717, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. H. B. El-Serag, “Time trends of gastroesophageal reflux disease: a systematic review,” Clinical Gastroenterology and Hepatology, vol. 5, no. 1, pp. 17–26, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. S. Engel, W. H. Chow, T. L. Vaughan et al., “Population attributable risks of esophageal and gastric cancers,” Journal of the National Cancer Institute, vol. 95, no. 18, pp. 1404–1413, 2003. View at Scopus
  7. W. J. Blot, “Esophageal cancer trends and risk factors,” Seminars in Oncology, vol. 21, no. 4, pp. 403–410, 1994. View at Scopus
  8. V. Stanghellini, “Relationship between upper gastrointestinal symptoms and lifestyle, psychosocial factors and comorbidity in the general population: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST),” Scandinavian Journal of Gastroenterology, Supplement, vol. 231, pp. 29–37, 1999. View at Scopus
  9. W. M. Wong, K. C. Lai, K. F. Lam et al., “Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study,” Alimentary Pharmacology and Therapeutics, vol. 18, no. 6, pp. 595–604, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Chen, L. Xiong, H. Chen, A. Xu, L. He, and P. Hu, “Prevalence, risk factors and impact of gastroesophageal reflux disease symptoms: a population-based study in South China,” Scandinavian Journal of Gastroenterology, vol. 40, no. 7, pp. 759–767, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. J. V. Lewis, “Editorial: gastroesophageal reflux disease and obesity,” Southern Medical Journal, vol. 102, no. 10, pp. 995–996, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Segal, “The gastro-oesophageal reflux disease complex in sub-Saharan Africa,” European Journal of Cancer Prevention, vol. 10, no. 3, pp. 209–212, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. S. C. Nwokediuko, “Gastroesophageal reflux disease, a population-based study,” Gastroenterology Research, vol. 2, pp. 152–156, 2009.
  14. S. C. Nwokediuko, U. Ijoma, O. Obienu, and C. Agunyenwa, “Gastroesophgeal reflux disease: a clinical and endoscopic study of Nigerian patients,” The Internet Journal of Gastroenterology, vol. 8, article 2, 2009.
  15. S. J. Sontag, A. Sonnenberg, T. G. Schnell, J. Leya, and A. Metz, “The long-term natural history of gastroesophageal reflux disease,” Journal of Clinical Gastroenterology, vol. 40, no. 5, pp. 398–404, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Agrawal and D. Castell, “GERD is chronic but not progressive,” Journal of Clinical Gastroenterology, vol. 40, no. 5, pp. 374–375, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Dent, J. Brun, A. M. Fendrick et al., “An evidence-based appraisal of reflux disease management— the Genval Workshop Report,” Gut, vol. 44, 2, pp. S1–S16, 1999. View at Scopus
  18. R. Fass, M. B. Fennerty, and N. Vakil, “Non erosive reflux disease-current concepts and dilemmas,” American Journal of Gastroenterology, vol. 96, no. 2, pp. 303–314, 2001. View at Publisher · View at Google Scholar · View at Scopus
  19. R. G. P. Watson, T. C. K. Tham, B. T. Johnston, and N. I. McDougall, “Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux—the ‘sensitive oesophagus’,” Gut, vol. 40, no. 5, pp. 587–590, 1997. View at Scopus
  20. D. Drossman Rome III, The Functional Gastrointestinal Disorders, Degnon Associates, McLean, Va, USA, 3rd edition, 2006.
  21. P. Zentilin, P. Dulbecco, E. Savarino, E. Giannini, and V. Savarino, “Combined multichannel intraluminal impedance and pH-metry: a novel technique to improve detection of gastro-oesophageal reflux. Literature review,” Digestive and Liver Disease, vol. 36, no. 9, pp. 565–569, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Savarino, P. Zentilin, R. Tutuian et al., “The role of nonacid reflux in NERD: lessons learned from impedance-pH monitoring in 150 patients off therapy,” American Journal of Gastroenterology, vol. 103, no. 11, pp. 2685–2693, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Nordenstedt and J. Lagergren, “Environmental factors in the etiology of gastroesophageal reflux disease,” Expert Review of Gastroenterology and Hepatology, vol. 2, no. 1, pp. 93–103, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Sharma, S. Wani, Y. Romero, D. Johnson, and F. Hamilton, “Racial and geographic issues in gastroesophageal reflux disease,” American Journal of Gastroenterology, vol. 103, no. 11, pp. 2669–2680, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. M. S. Rosaida and K. L. Goh, “Gastro-oesophageal reflux disease, reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population: a prospective, endoscopy based study,” European Journal of Gastroenterology and Hepatology, vol. 16, no. 5, pp. 495–501, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Hirakawa, K. Adachi, K. Amano et al., “Prevalence of non-ulcer dyspepsia in the Japanese population,” Journal of Gastroenterology and Hepatology, vol. 14, no. 11, pp. 1083–1087, 1999. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Rajendra, K. Kutty, and N. Karim, “Ethnic differences in the prevalence of endoscopic esophagitis and Barrett's esophagus: the long and short of it all,” Digestive Diseases and Sciences, vol. 49, no. 2, pp. 237–242, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. H. B. El-Serag, D. Y. Graham, J. A. Satia, and L. Rabeneck, “Obesity is an independent risk factor for GERD symptoms and erosive esophagitis,” American Journal of Gastroenterology, vol. 100, no. 6, pp. 1243–1250, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Ayazi, P. Crookes, and C. Peyre, “Objective documentation of the link between GERD and obesity,” The American Journal of Gastroenterology, vol. 102, pp. 138–139, 2007.
  30. S. Ayazi, J. A. Hagen, L. S. Chan et al., “Obesity and gastroesophageal reflux: quantifying the association between body mass index, esophageal acid exposure, and lower esophageal sphincter status in a large series of patients with reflux symptoms,” Journal of Gastrointestinal Surgery, vol. 13, no. 8, pp. 1440–1447, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. N. S. Buttar and G. W. Falk, “Pathogenesis of gastroesophageal reflux and Barrett esophagus,” Mayo Clinic Proceedings, vol. 76, no. 2, pp. 226–234, 2001. View at Scopus
  32. M. G. Patti, H. I. Goldberg, M. Arcerito, L. Bortolasi, J. Tong, and L. W. Way, “Hiatal hernia size affects lower esophageal sphincter function, esophageal acid exposure, and the degree of mucosal injury,” American Journal of Surgery, vol. 171, no. 1, pp. 182–186, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Watanabe, Y. Fujiwara, M. Shiba et al., “Cigarette smoking and alcohol consumption associated with gastro-oesophageal reflux disease in Japanese men,” Scandinavian Journal of Gastroenterology, vol. 38, no. 8, pp. 807–811, 2003. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Ruigómez, M. A. Wallander, S. Johansson, and L. A. G. Rodríguez, “Irritable bowel syndrome and gastroesophageal reflux disease in primary care: is there a link?” Digestive Diseases and Sciences, vol. 54, no. 5, pp. 1079–1086, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. M. G. Patti, W. J. Gasper, P. M. Fisichella, I. Nipomnick, and F. Palazzo, “Gastroesophageal reflux disease and connective tissue disorders: pathophysiology and implications for treatment,” Journal of Gastrointestinal Surgery, vol. 12, no. 11, pp. 1900–1906, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. W. J. Dodds, W. J. Hogan, J. F. Helm, and J. Dent, “Pathogenesis of reflux esophagitis,” Gastroenterology, vol. 81, no. 2, pp. 376–394, 1981. View at Scopus
  37. H. J. Stein and T. R. DeMeester, “Outpatient physiologic testing and surgical management of foregut motility disorders,” Current Problems in Surgery, vol. 29, no. 7, pp. 413–555, 1992. View at Publisher · View at Google Scholar · View at Scopus
  38. D. Stefanidis, W. W. Hope, G. P. Kohn, P. R. Reardon, W. S. Richardson, and R. D. Fanelli, “Guidelines for surgical treatment of gastroesophageal reflux disease,” Surgical Endoscopy, vol. 24, no. 11, pp. 2647–2669, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. R. Carlsson, J. Dent, E. Bolling-Sternevald et al., “The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease,” Scandinavian Journal of Gastroenterology, vol. 33, no. 10, pp. 1023–1029, 1998. View at Publisher · View at Google Scholar · View at Scopus
  40. W. M. Wong, K. F. Lam, K. C. Lai et al., “A validated symptoms questionnaire (Chinese GERDQ) for the diagnosis of gastro-oesophageal reflux disease in the Chinese population,” Alimentary Pharmacology and Therapeutics, vol. 17, no. 11, pp. 1407–1413, 2003. View at Publisher · View at Google Scholar · View at Scopus
  41. I. Yoshikawa, M. Yamasaki, T. Yamasaki, K. Kume, and M. Otsuki, “Lugol chromoendoscopy as a diagnostic tool in so-called endoscopy-negative GERD,” Gastrointestinal Endoscopy, vol. 62, no. 5, pp. 698–703, 2005. View at Publisher · View at Google Scholar · View at Scopus
  42. P. Sharma, S. Wani, A. Bansal et al., “A feasibility trial of narrow band imaging endoscopy in patients with gastroesophageal reflux disease,” Gastroenterology, vol. 133, no. 2, pp. 454–464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Kiesslich, K. Lammersdorf, M. Goetz, et al., “Microscopic changes in non-erosive reflux disease can be diagnosed during on-going endomicroscop,” Gastrointestinal Endoscopy, vol. 65, Article ID AB243, 2006.
  44. F. Ismail-Beigi, P. F. Horton, and C. E. Pope 2nd. C.E., “Histological consequences of gastroesophageal reflux in man,” Gastroenterology, vol. 58, no. 2, pp. 163–174, 1970. View at Scopus
  45. L. F. Brown, H. Goldman, and D. A. Antonioli, “Intraepithelial eosinophils in endoscopic biopsies of adults with reflux esophagitis,” American Journal of Surgical Pathology, vol. 8, no. 12, pp. 899–905, 1984. View at Scopus
  46. C. M. Ballem, H. W. Fletcher, and R. D. Mc Kenna, “The diagnosis of esophagitis,” The American Journal of Digestive Diseases, vol. 5, no. 2, pp. 88–93, 1960. View at Publisher · View at Google Scholar · View at Scopus
  47. T. E. Knuff, S. B. Benjamin, G. F. Worsham, J. E. Hancock, and D. O. Castell, “Histologic evaluation of chronic gastroesophageal reflux. An evaluation of biopsy methods and diagnostic criteria,” Digestive Diseases and Sciences, vol. 29, no. 3, pp. 194–201, 1984. View at Scopus
  48. S. Nandurkar, N. J. Talley, C. J. Martin, and S. Adams, “Esophageal histology does not provide additional useful information over clinical assessment in identifying reflux patients presenting for esophagogastroduodenoscopy,” Digestive Diseases and Sciences, vol. 45, no. 2, pp. 217–224, 2000. View at Publisher · View at Google Scholar · View at Scopus
  49. P. Zentilin, V. Savarino, L. Mastracci et al., “Reassessment of the diagnostic value of histology in patients with GERD, using multiple biopsy sites and an appropriate control group,” American Journal of Gastroenterology, vol. 100, no. 10, pp. 2299–2306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. S. C. Nwokediuko, U. Ijoma, and O. Okafor, “Esophageal intraepithelial neutrophil infiltration is common in Nigerian patients with non-erosive reflux disease,” Gastroenterology Research, vol. 4, no. 1, pp. 20–25, 2011.
  51. K. R. De Vault and D. O. Castell, “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease,” American Journal of Gastroenterology, vol. 100, no. 1, pp. 190–200, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. K. M. Fock, N. J. Talley, R. Fass et al., “Asia-Pacific consensus on the management of gastroesophageal reflux disease: update,” Journal of Gastroenterology and Hepatology, vol. 23, no. 1, pp. 8–22, 2008. View at Publisher · View at Google Scholar · View at Scopus
  53. J. P. Waring, J. G. Hunter, M. Oddsdottir, J. Wo, and E. Katz, “The preoperative evaluation of patients considered for laparoscopic antireflux surgery,” American Journal of Gastroenterology, vol. 90, no. 1, pp. 35–38, 1995. View at Scopus
  54. P. J. Kahrilas, N. J. Shaheen, and M. F. Vaezi, “American gastroenterological association medical position statement on the management of gastroesophageal reflux disease,” Gastroenterology, vol. 135, no. 4, pp. 1383.e5–1391.e5, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. D. Pohl and R. Tutuian, “Reflux monitoring: pH-metry, bilitec and oesophageal impedance measurements,” Best Practice and Research, vol. 23, no. 3, pp. 299–311, 2009. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Agrawal and D. O. Castell, “Clinical importance of impedance measurements,” Journal of Clinical Gastroenterology, vol. 42, no. 5, pp. 579–583, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. R. F. Harvey, N. Hadley, T. R. Gill et al., “Effects of sleeping with the bed-head raised and of ranitidine in patients with severe peptic oesophagitis,” The Lancet, vol. 2, no. 8569, pp. 1200–1203, 1987. View at Scopus
  58. D. Y. Graham and D. J. Patterson, “Double-blind comparison of liquid antacid and placebo in the treatment of symptomatic reflux esophagitis,” Digestive Diseases and Sciences, vol. 28, no. 6, pp. 559–563, 1983. View at Scopus
  59. D. A. Lieberman, “Medical therapy for chronic reflux esophagitis. Long-term follow-up,” Archives of Internal Medicine, vol. 147, no. 10, pp. 1717–1720, 1987. View at Scopus
  60. T. Poynbard, “Relapse rate of patients after healing of oesophagitis—a prospective study of alginate as self-care treatment for 6 months,” Alimentary Pharmacology and Therapeutics, vol. 7, no. 4, pp. 385–392, 1993. View at Scopus
  61. S. Bruley des Varannes, E. Coron, and J. P. Galmiche, “Short and long-term PPI treatment for GERD. Do we need more-potent anti-secretory drugs?” Best Practice and Research, vol. 24, no. 6, pp. 905–921, 2010. View at Publisher · View at Google Scholar · View at Scopus
  62. K. R. De Vault and D. O. Castell, “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease,” The American Journal of Gastroenterology, vol. 94, no. 6, pp. 1434–1442, 1999. View at Publisher · View at Google Scholar · View at Scopus
  63. D. G. Colin-Jones, “The role and limitation of H2-receptor antagonists in the treatment of gastroesophgeal reflux disease,” Alimentary Pharmacology & Therapeutics, vol. 9, pp. 9–14, 1995.
  64. R. Tutuian and D. O. Castell, “Management of gastroesophageal reflux disease,” American Journal of the Medical Sciences, vol. 326, no. 5, pp. 309–318, 2003. View at Publisher · View at Google Scholar · View at Scopus
  65. P. Richardson, C. J. Hawkey, and W. A. Stack, “Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal disorders,” Drugs, vol. 56, no. 3, pp. 307–335, 1998. View at Publisher · View at Google Scholar · View at Scopus
  66. E. C. Klinkenberg-Knol, F. Nelis, J. Dent et al., “Long-term omeprazole treatment in resistant gastroesophageal reflux disease: efficacy, safety, and influence on gastric mucosa,” Gastroenterology, vol. 118, no. 4, pp. 661–669, 2000. View at Scopus
  67. M. Khan, J. Santana, C. Donnellan, C. Preston, and P. Moayyedi, “Medical treatments in the short term management of reflux oesophagitis,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD003244, 2007. View at Scopus
  68. T. L. Venables, R. D. Newland, A. C. Patel, J. Hole, C. Wilcock, and M. L. Turbitt, “Omeprazole 10 milligrams once daily, omeprazole 20 milligrams once daily, or ranitidine 150 milligrams twice daily, evaluated as initial therapy for the relief of symptoms of gastro-oesophageal reflux disease in general practice,” Scandinavian Journal of Gastroenterology, vol. 32, no. 10, pp. 965–973, 1997. View at Scopus
  69. B. Van Pinxteren, M. E. Numans, P. A. Bonis, and J. Lau, “Short-term treatment with proton pump inhibitors, H2-receptor antagonists and prokinetics for gastro-oesophageal reflux disease-like symptoms and endoscopy negative reflux disease,” Cochrane Database of Systematic Reviews, vol. 3, Article ID CD002095, 2006. View at Scopus
  70. R. Fass, “Proton-pump inhibitor therapy in patients with gastro-oesophageal reflux disease: putative mechanisms of failure,” Drugs, vol. 67, no. 11, pp. 1521–1530, 2007. View at Publisher · View at Google Scholar · View at Scopus
  71. R. Jones, D. Armstrong, P. Malfertheiner, and P. Ducrotté, “Does the treatment of gastroesophageal reflux disease (GERD) meet patients' needs? A survey-based study,” Current Medical Research and Opinion, vol. 22, no. 4, pp. 657–662, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. R. Fass and D. Sifrim, “Management of heartburn not responding to proton pump inhibitors,” Gut, vol. 58, no. 2, pp. 295–309, 2009. View at Publisher · View at Google Scholar · View at Scopus
  73. J. E. Richter, “The patient with refractory gastroesophageal reflux disease,” Diseases of the Esophagus, vol. 19, no. 6, pp. 443–447, 2006. View at Publisher · View at Google Scholar · View at Scopus
  74. M. E. Manzotti, H. N. Catalano, F. A. Serrano, G. D. Stilio, M. F. Koch, and G. Guyatt, “Prokinetic drug utility in the treatment of gastroesophgeal reflux esophatitis: a systematic review of randomized controlled trial,” Open Medicine, vol. 1, no. 3, 2007.
  75. S. Bruley des Varannes, E. Coron, and J. P. Galmiche, “Short and long-term PPI treatment for GERD. Do we need more-potent anti-secretory drugs?” Best Practice and Research, vol. 24, no. 6, pp. 905–921, 2010. View at Publisher · View at Google Scholar · View at Scopus
  76. F. Lodato, F. Azzaroli, L. Turco et al., “Adverse effects of proton pump inhibitors,” Best Practice and Research, vol. 24, no. 2, pp. 193–201, 2010. View at Publisher · View at Google Scholar · View at Scopus
  77. N. Havu, “Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion,” Digestion, vol. 35, no. 1, pp. 42–55, 1986. View at Scopus
  78. W. R. Garnett, “Considerations for long-term use of proton-pump inhibitors,” American Journal of Health-System Pharmacy, vol. 55, no. 21, pp. 2268–2279, 1998. View at Scopus
  79. J. W. Freston, “Long-term acid control and proton pump inhibitors: interactions and safety issues in perspective,” American Journal of Gastroenterology, vol. 92, 4, pp. 515–575, 1997. View at Scopus
  80. J. W. Freston, P. A. Rose, C. A. Heller, M. Haber, and D. Jennings, “Safety profile of lansoprazole: the US clinical trial experience,” Drug Safety, vol. 20, no. 2, pp. 195–205, 1999. View at Publisher · View at Google Scholar · View at Scopus
  81. B. Thjodleifsson, G. Rindi, R. Fiocca et al., “A randomized, double-blind trial of the efficacy and safety of 10 or 20 mg rabeprazole compared with 20 mg omeprazole in the maintenance of gastro-oesophageal reflux disease over 5 years,” Alimentary Pharmacology and Therapeutics, vol. 17, no. 3, pp. 343–351, 2003. View at Publisher · View at Google Scholar · View at Scopus
  82. Y. X. Yang, J. D. Lewis, S. Epstein, and D. C. Metz, “Long-term proton pump inhibitor therapy and risk of hip fracture,” Journal of the American Medical Association, vol. 296, no. 24, pp. 2947–2953, 2006. View at Publisher · View at Google Scholar · View at Scopus
  83. P. Vestergaard, L. Rejnmark, and L. Mosekilde, “Proton pump inhibitors, histamine H2 receptor antagonists, and other antacid medications and the risk of fracture,” Calcified Tissue International, vol. 79, no. 2, pp. 76–83, 2006. View at Publisher · View at Google Scholar · View at Scopus
  84. L. E. Targownik, L. M. Lix, C. J. Metge, H. J. Prior, S. Leung, and W. D. Leslie, “Use of proton pump inhibitors and risk of osteoporosis-related fractures,” Canadian Medical Association Journal, vol. 179, no. 4, pp. 319–326, 2008. View at Publisher · View at Google Scholar · View at Scopus
  85. S. L. Gray, A. Z. Lacroix, J. Larson et al., “Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women: results from the women's health initiative,” Archives of Internal Medicine, vol. 170, no. 9, pp. 765–771, 2010. View at Publisher · View at Google Scholar · View at Scopus
  86. J. Leonard, J. K. Marshall, and P. Moayyedi, “Systematic review of the risk of enteric infection in patients taking acid suppression,” American Journal of Gastroenterology, vol. 102, no. 9, pp. 2047–2056, 2007. View at Publisher · View at Google Scholar · View at Scopus
  87. N. Sultan, J. Nazareno, and J. Gregor, “Association between proton pump inhibitors and respiratory infections: a systematic review and meta-analysis of clinical trials,” Canadian Journal of Gastroenterology, vol. 22, no. 9, pp. 761–766, 2008. View at Scopus
  88. L. Lombardo, M. Foti, O. Ruggia, and A. Chiecchio, “Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy,” Clinical Gastroenterology and Hepatology, vol. 8, no. 6, pp. 504–508, 2010. View at Publisher · View at Google Scholar · View at Scopus
  89. K. E. L. McColl, “Effect of proton pump inhibitors on vitamins and iron,” American Journal of Gastroenterology, vol. 104, 2, pp. S5–S9, 2009. View at Publisher · View at Google Scholar · View at Scopus
  90. A. A. Alkhatib, F. A. Elkhatib, and O. F. Khatib, “Gastric acid-reducing medications and clopidogrel: what are the latest FDA recommendations,” American Journal of Gastroenterology, vol. 105, no. 5, p. 1211, 2010. View at Publisher · View at Google Scholar · View at Scopus
  91. R. Jones, H. R. Liker, and P. Ducrotté, “Relationship between symptoms, subjective well-being and medication use in gastro-oesophageal reflux disease,” International Journal of Clinical Practice, vol. 61, no. 8, pp. 1301–1307, 2007. View at Publisher · View at Google Scholar · View at Scopus
  92. A. Lehmann, “Novel treatments of GERD: focus on the lower esophageal sphincter,” European Review for Medical and Pharmacological Sciences, vol. 12, no. 1, pp. 103–110, 2008. View at Scopus
  93. G. Sachs, J. M. Shin, C. Briving, B. Wallmark, and S. Hersey, “The pharmacology of the gastric acid pump: the H+,K+ ATPase,” Annual Review of Pharmacology and Toxicology, vol. 35, pp. 277–305, 1995. View at Scopus
  94. J. M. Shin, M. Besancon, K. Bamberg, and G. Sachs, “Structural aspects of the gastric H,K ATPase,” Annals of the New York Academy of Sciences, vol. 834, pp. 65–76, 1997. View at Publisher · View at Google Scholar · View at Scopus
  95. J. Dent, P. J. Kahrilas, J. Hatlebakk et al., “A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease,” American Journal of Gastroenterology, vol. 103, no. 1, pp. 20–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  96. P. J. Kahrilas, J. Dent, K. Lauritsen et al., “A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis,” Clinical Gastroenterology and Hepatology, vol. 5, no. 12, pp. 1385–1391, 2007. View at Publisher · View at Google Scholar · View at Scopus
  97. Takeda Pharmaceutical company Ltd, Product pipeline Takeda Pharmaceutical company Ltd, 2009.
  98. Yuhan Corporation, R&D Activity Pipeline, Yuhan Corporation, Yuhan Corporation, 2009.
  99. N. Vakil, “Review article: new pharmacological agents for the treatment of gastro-oesophageal reflux disease,” Alimentary Pharmacology and Therapeutics, vol. 19, no. 10, pp. 1041–1049, 2004. View at Publisher · View at Google Scholar · View at Scopus
  100. Janssen Pharmaceutical, Letter. Propulsid tablets and suspension (cisapride), Janssen Pharmacetica. 2000.
  101. C. A. Thompson, “Novartis suspends tegaserod sales at FDA's request,” American Journal of Health-System Pharmacy, vol. 64, no. 10, p. 1020, 2007. View at Publisher · View at Google Scholar · View at Scopus
  102. ARYZX Therapeutics Inc, 2009 Annual Report on Form 10-K, ARYX Therapeutics Inc, 2008.
  103. NCT00539240: Role of pain modulation in GERD patients who failed standard dose PPI., 2009, http://www.clinicaltrials.gov/.
  104. S. E. Attwood and J. P. Galmiche, “A debate on the roles of antireflux surgery and long-term acid suppression in the management of gastroesophgeal reflux disease,” Frontline Gastroenterology, vol. 2, no. 4, pp. 206–211, 2011. View at Publisher · View at Google Scholar
  105. “Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD the LOTUS randomized clinical trial,” The Journal of the American Medical Association, vol. 305, no. 19, pp. 1969–1977, 2011. View at Publisher · View at Google Scholar
  106. S. J. Spechler and R. K. Goyal, “The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett,” Gastroenterology, vol. 110, no. 2, pp. 614–621, 1996. View at Scopus
  107. J. Lagergren, R. Bergstom, A. Lindgen, and O. Nyren, “Symptomatic gastroesophgeal reflux as a risk factor for esophgeal adenocarcinoma,” The New England Journal of Medicine, vol. 340, pp. 825–831, 1999.
  108. S. Rakita, D. Villadolid, A. Thomas et al., “Laparoscopic nissen fundoplication offers high patient satisfaction with relief of extraesophageal symptoms of gastroesophageal reflux disease,” American Surgeon, vol. 72, no. 3, pp. 207–212, 2006. View at Scopus
  109. T. K. Meyer, E. Olsen, and A. Merati, “Contemporary diagnostic and management techniques for extraesophageal reflux disease,” Current Opinion in Otolaryngology and Head and Neck Surgery, vol. 12, no. 6, pp. 519–524, 2004. View at Publisher · View at Google Scholar · View at Scopus
  110. D. R. Lindstrom, J. Wallace, T. A. Loehrl, A. L. Merati, and R. J. Toohill, “Nissen fundoplication surgery for extraesophageal manifestations of gastroesophageal reflux (EER),” Laryngoscope, vol. 112, no. 10, pp. 1762–1765, 2002. View at Scopus
  111. B. K. Oelschlager, T. R. Eubanks, D. Oleynikov, C. Pope, and C. A. Pellegrini, “Symptomatic and physiologic outcomes after operative treatment for extraesophageal reflux,” Surgical Endoscopy and Other Interventional Techniques, vol. 16, no. 7, pp. 1032–1036, 2002. View at Publisher · View at Google Scholar · View at Scopus
  112. P. Yau, D. I. Watson, P. G. Devitt, P. A. Game, and G. G. Jamieson, “Laparoscopic antireflux surgery in the treatment of gastroesophageal reflux in patients with Barrett esophagus,” Archives of Surgery, vol. 135, no. 7, pp. 801–805, 2000. View at Scopus
  113. M. Luostarinen, J. Isolauri, J. Laitinen et al., “Fate of Nissen fundoplication after 20 years. A clinical, endoscopical, and functional analysis,” Gut, vol. 34, no. 8, pp. 1015–1020, 1993. View at Scopus
  114. J. Johansson, F. Johnsson, B. Joelsson, C. H. Floren, and B. Walther, “Outcome 5 years after 360° fundoplication for gastro-oesophageal reflux disease,” British Journal of Surgery, vol. 80, no. 1, pp. 46–49, 1993. View at Scopus
  115. M. Catarci, P. Gentileschi, C. Papi et al., “Evidence-based appraisal of antireflux fundoplication,” Annals of Surgery, vol. 239, no. 3, pp. 325–337, 2004. View at Publisher · View at Google Scholar · View at Scopus
  116. L. Rydberg, M. Ruth, and L. Lundell, “Mechanism of action of antireflux procedures,” British Journal of Surgery, vol. 86, no. 3, pp. 405–410, 1999. View at Publisher · View at Google Scholar · View at Scopus
  117. H. K. Jung, S. Halder, M. McNally et al., “Overlap of gastro-oesophageal reflux disease and irritable bowel syndrome: prevalence and risk factors in the general population,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 3, pp. 453–461, 2007. View at Publisher · View at Google Scholar · View at Scopus
  118. D. R. De Vries, M. A. Van Herwaarden, A. Baron, A. J. P. M. Smout, and M. Samsom, “Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease,” Scandinavian Journal of Gastroenterology, vol. 42, no. 8, pp. 951–956, 2007. View at Publisher · View at Google Scholar · View at Scopus
  119. V. Stanghellini, G. Barbara, R. Cogliandro et al., “Overlap between GERD and IBS: irrefutable but subtle,” Journal of Clinical Gastroenterology, vol. 41, 2, pp. S114–S117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  120. C. H. Knowles and Q. Aziz, “Visceral hypersensitivity in nonerosive reflux disease,” Gut, vol. 57, no. 5, pp. 674–683, 2008. View at Publisher · View at Google Scholar · View at Scopus
  121. R. G. P. Watson, T. C. K. Tham, B. T. Johnston, and N. I. McDougall, “Double blind cross-over placebo controlled study of omeprazole in the treatment of patients with reflux symptoms and physiological levels of acid reflux—the ‘sensitive oesophagus’,” Gut, vol. 40, no. 5, pp. 587–590, 1997. View at Scopus
  122. J. Zimmerman and T. Hershcovici, “Bowel symptoms in nonerosive gastroesophageal reflux disease: nature, prevalence, and relation to acid reflux,” Journal of Clinical Gastroenterology, vol. 42, no. 3, pp. 261–265, 2008. View at Publisher · View at Google Scholar · View at Scopus