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ISRN Gastroenterology
Volume 2012 (2012), Article ID 562594, 7 pages
http://dx.doi.org/10.5402/2012/562594
Review Article

Necrotizing Enterocolitis in Very Low Birth Weight Infants: A Systemic Review

Department of Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Gujarat, Mehsana 384001, India

Received 18 April 2012; Accepted 19 June 2012

Academic Editors: C.-Y. Chen and C. Sperti

Copyright © 2012 Bhoomika K. Patel and Jigna S. Shah. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Joint FAO/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food, London, Ontario, Canada, 2002.
  2. J. L. Blakey, L. Lubitz, and G. L. Barnes, “Development of gut colonisation in pre-term neonates,” Journal of Medical Microbiology, vol. 15, no. 4, pp. 519–529, 1982. View at Scopus
  3. I. H. Gewolb, R. S. Schwalbe, V. L. Taciak, T. S. Harrison, and P. Panigrahi, “Stool microflora in extremely low birthweight infants,” Archives of Disease in Childhood, vol. 80, no. 3, pp. F167–F173, 1999. View at Scopus
  4. F. Magne, A. Suau, P. Pochart, and J. F. Desjeux, “Fecal microbial community in preterm infants,” Journal of Pediatric Gastroenterology and Nutrition, vol. 41, no. 4, pp. 386–392, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. I. H. Gewolb, R. S. Schwalbe, V. L. Taciak, T. S. Harrison, and P. Panigrahi, “Stool microflora in extremely low birthweight infants,” Archives of Disease in Childhood, vol. 80, no. 3, pp. F167–F173, 1999. View at Scopus
  6. A. Narang, R. Rao, and O. N. Bhakoo, “Neonatal necrotizing enterocolitis an epidemiological study,” Indian Pediatrics, vol. 30, no. 10, pp. 1207–1214, 1993. View at Scopus
  7. C. L. Snyder, G. K. Gittes, J. Patrick Murphy, R. J. Sharp, K. W. Ashcraft, and R. A. Amoury, “Survival after necrotizing enterocolitis in infants weighing less than 1,000 g: 25 years' experience at a single institution,” Journal of Pediatric Surgery, vol. 32, no. 3, pp. 434–437, 1997. View at Publisher · View at Google Scholar · View at Scopus
  8. J. N. Schullinger, D. L. Mollitt, and C. D. Vinocur, “Neonatal necrotizing enterocolitis. Survival, management, and complications: a 25-year study,” American Journal of Diseases of Children, vol. 135, no. 7, pp. 612–614, 1981. View at Scopus
  9. W. P. Kanto, R. Wilson, and R. R. Ricketts, “Management and outcome of necrotizing enterocolitis,” Clinical Pediatrics, vol. 24, no. 2, pp. 79–82, 1985. View at Scopus
  10. J. L. Grosfeld, H. Cheu, M. Schlatter, K. W. West, and F. J. Rescorla, “Changing trends in necrotizing enterocolitis: experience with 302 cases in two decades,” Annals of Surgery, vol. 214, no. 3, pp. 300–307, 1991. View at Scopus
  11. A. Bashiri, E. Zmora, E. Sheiner, R. Hershkovitz, I. Shoham-Vardi, and M. Mazor, “Maternal hypertensive disorders are an independent risk factor for the development of necrotizing enterocolitis in very low birth weight infants,” Fetal Diagnosis and Therapy, vol. 18, no. 6, pp. 404–407, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Sankaran, B. Puckett, D. S. Lee et al., “Variations in incidence of necrotizing enterocolitis in Canadian neonatal intensive care units,” Journal of Pediatric Gastroenterology and Nutrition, vol. 39, no. 4, pp. 366–372, 2004. View at Scopus
  13. M. Luig and K. Lui, “Epidemiology of necrotizing enterocolitis—part II: risks and susceptibility of premature infants during the surfactant era: a regional study,” Journal of Paediatrics and Child Health, vol. 41, no. 4, pp. 174–179, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. S. O. Guthrie, P. V. Gordon, V. Thomas, J. A. Thorp, J. Peabody, and R. H. Clark, “Necrotizing enterocolitis among neonates in the United States,” Journal of Perinatology, vol. 23, no. 4, pp. 278–285, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. D. J. Hackam, J. S. Upperman, A. Grishin, and H. R. Ford, “Disordered enterocyte signaling and intestinal barrier dysfunction in the pathogenesis of necrotizing enterocolitis,” Seminars in Pediatric Surgery, vol. 14, no. 1, pp. 49–57, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Papparella, F. G. Deluca, C. E. Oyer, H. Pinar, and B. S. Stonestreet, “Ischemia-reperfusion injury in the intestines of newborn pigs,” Pediatric Research, vol. 42, no. 2, pp. 180–188, 1997. View at Scopus
  17. N. N. Nanthakumar, R. D. Fusunyan, I. Sanderson, and W. A. Walker, “Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 11, pp. 6043–6048, 2000. View at Publisher · View at Google Scholar · View at Scopus
  18. M. D. Halpern, H. Holubec, K. Dvorakova, et al., “Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis,” Pediatric Research, vol. 51, no. 6, pp. 733–739, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. M. B. Edelson, C. E. Bagwell, and H. J. Rozycki, “Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis,” Pediatrics, vol. 103, no. 4, pp. 766–771, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. M. D. Halpern, H. Holubec, J. A. Dominguez, Y. G. Meza, C. S. Williams, and M. C. Ruth, “Hepatic inflammatory mediators contribute to intestinal damage in Necrotisingenterocolitis,” Journal of Physiology, Gastrointestinal and Liver Physiology, vol. 288, no. 4, pp. G755–G762, 2005.
  21. P. F. Pollack, T. Goda, and P. C. Colony, “Effects of enterally fed epidermal growth factor on the small and large intestine of the suckling rat,” Regulatory Peptides, vol. 17, no. 3, pp. 121–132, 1987. View at Scopus
  22. M. S. Caplan, M. Lickerman, L. Adler, G. N. Dietsch, and A. Yu, “The role of recombinant platelet-activating factor acetylhydrolase in a neonatal rat model of necrotizing enterocolitis,” Pediatric Research, vol. 42, no. 6, pp. 779–783, 1997. View at Scopus
  23. J. S. Lee and R. A. Polin, “Treatment and prevention of necrotizing enterocolitis,” Seminars in Neonatology, vol. 8, no. 6, pp. 449–459, 2003. View at Publisher · View at Google Scholar · View at Scopus
  24. C. M. Hoy, C. M. Wood, P. M. Hawkey, and J. W. L. Puntis, “Duodenal microflora in very-low-birth-weight neonates and relation to necrotizing enterocolitis,” Journal of Clinical Microbiology, vol. 38, no. 12, pp. 4539–4547, 2000. View at Scopus
  25. K. Undergrove, “Necrotisingenterocolitis: the evidence for the use of human milk in prevention and treatment,” Journal of Human Lactation, vol. 20, no. 3, pp. 335–339, 2004.
  26. A. Lucas and T. J. Cole, “Breast milk and neonatal necrotising enterocolitis,” Lancet, vol. 336, no. 8730-8731, pp. 1519–1523, 1990. View at Scopus
  27. W. McGuire and M. Y. Anthony, “Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review,” Archives of Disease in Childhood, vol. 88, no. 1, pp. F11–F14, 2003. View at Scopus
  28. K. A. Kennedy, J. E. Tyson, and S. Chamnanvanakij, “Rapid versus slow rate of advancement of feedings for promoting growth and preventing necrotizing enterocolitis in parenterally fed low-birth-weight infants,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD001241, 2000. View at Scopus
  29. B. Kuzma-O'Reilly, M. L. Duenas, C. Greecher et al., “Evaluation, development, and implementation of potentially better practices in neonatal intensive care nutrition,” Pediatrics, vol. 111, no. 4, pp. e461–e470, 2003. View at Scopus
  30. S. K. Patole and N. De Klerk, “Impact of standardised feeding regimens on incidence of neonatal necrotising enterocolitis: a systematic review and meta-analysis of observational studies,” Archives of Disease in Childhood, vol. 90, no. 2, pp. F147–F151, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. J. L. Blakey, L. Lubitz, and G. L. Barnes, “Development of gut colonisation in pre-term neonates,” Journal of Medical Microbiology, vol. 15, no. 4, pp. 519–529, 1982. View at Scopus
  32. I. H. Gewolb, R. S. Schwalbe, V. L. Taciak, T. S. Harrison, and P. Panigrahi, “Stool microflora in extremely low birthweight infants,” Archives of Disease in Childhood, vol. 80, no. 3, pp. F167–F173, 1999. View at Scopus
  33. F. Magne, A. Suau, P. Pochart, and J. F. Desjeux, “Fecal microbial community in preterm infants,” Journal of Pediatric Gastroenterology and Nutrition, vol. 41, no. 4, pp. 386–392, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. M. S. Caplan and T. Jilling, “Neonatal necrotizing enterocolitis: possible role of probiotic supplementation,” Journal of Pediatric Gastroenterology and Nutrition, vol. 30, no. 2, pp. S18–S22, 2000. View at Scopus
  35. G. R. Gibson and M. B. Roberfroid, “Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics,” Journal of Nutrition, vol. 125, no. 6, pp. 1401–1412, 1995. View at Scopus
  36. O. E. Adiv, M. Berant, and R. Shamir, “New supplements to infant formulas,” Pediatric Endocrinology Reviews, vol. 2, no. 2, pp. 216–224, 2004. View at Scopus
  37. D. Dai and W. A. Walker, “Protective nutrients and bacterial colonization in the immature human gut,” Advances in Pediatrics, vol. 46, pp. 353–382, 1999. View at Scopus
  38. E. M. M. Quigley and R. Quera, “Small intestinal bacterial overgrowth: roles of antibiotics, prebiotics, and probiotics,” Gastroenterology, vol. 130, no. 2, pp. S78–S90, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Boehm, M. Lidestri, P. Casetta et al., “Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants,” Archives of Disease in Childhood, vol. 86, no. 3, pp. F178–F181, 2002. View at Scopus
  40. W. Mihatsch, J. Hoegel, and F. Pohlandt, “Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants,” Acta Paediatrica, vol. 95, no. 7, pp. 843–848, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Indrio, G. Riezzo, O. Montagna, E. Valenzano, A. Mautone, and G. Boehm, “Effect of a prebiotic mixture of short chain galacto-oligosaccharides and long chain fructo-oligosaccharides on gastric motility in preterm infants,” Journal of Pediatric Gastroenterology and Nutrition, article e122, 2007.
  42. A. Kapiki, C. Costalos, C. Oikonomidou, A. Triantafyllidou, E. Loukatou, and V. Pertrohilou, “The effect of a fructo-oligosaccharide supplemented formula on gut flora of preterm infants,” Early Human Development, vol. 83, no. 5, pp. 335–339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  43. J. Schrezenmeir and M. De Vrese, “Probiotics, prebiotics, and synbiotics—approaching a definition,” American Journal of Clinical Nutrition, vol. 73, no. 2, supplement, pp. 361S–364S, 2001. View at Scopus
  44. M. A. Underwood, N. H. Salzman, S. H. Bennett et al., “A randomized placebo-controlled comparison of 2 prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short-chain fatty acids,” Journal of Pediatric Gastroenterology and Nutrition, vol. 48, no. 2, pp. 216–225, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Crowley, I. Chalmers, and M. J. N. C. Keirse, “The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials,” British Journal of Obstetrics and Gynaecology, vol. 97, no. 1, pp. 11–25, 1990. View at Scopus
  46. E. F. Bell, D. Warburton, B. S. Stonestreet, and W. Oh, “High-volume fluid intake predisposes premature infants to necrotising enterocolitis,” Lancet, vol. 2, no. 8133, p. 90, 1979. View at Scopus
  47. E. F. Bell and M. J. Acarregui, “Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD000503, 2000. View at Scopus
  48. E. A. Egan, R. M. Nelson, G. Mantilla, and D. V. Eitzman, “Additional experience with routine use of oral kanamycin prophylaxis for necrotizing enterocolitis in infants under 1,500 grams,” The Journal of Pediatrics, vol. 90, no. 2, pp. 331–332, 1977. View at Scopus
  49. Y. K. Siu, P. C. Ng, S. C. K. Fung et al., “Double blind, randomised, placebo controlled study of oral vancomycin in prevention of necrotising enterocolitis in preterm, very low birthweight infants,” Archives of Disease in Childhood, vol. 79, no. 2, pp. F105–F109, 1998. View at Scopus
  50. R. G. Bury and D. Tudehope, “Enteral antibiotics for preventing necrotising enterocolitis in low birthweight or preterm infants,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD000405, 2000. View at Scopus
  51. G. R. Burgio, A. Lanzavecchia, and A. Plebani, “Ontogeny of secretory immunity: levels of secretory IgA and natural antibodies in saliva,” Pediatric Research, vol. 14, no. 10, pp. 1111–1114, 1980. View at Scopus
  52. J. Foster and M. Cole, “Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth-weight neonates,” Cochrane Database of Systematic Reviews, no. 1, Article ID CD001816, 2004. View at Scopus
  53. H. J. Amin, S. A. Zamora, D. D. McMillan et al., “Arginine supplementation prevents necrotizing enterocolitis in the premature infant,” Journal of Pediatrics, vol. 140, no. 4, pp. 425–431, 2002. View at Publisher · View at Google Scholar · View at Scopus
  54. R. W. Ryder, J. D. Shelton, and M. E. Guinan, “Necrotisingenterocolitis: a prospective multicenter investigation,” American Journal of Epidemiology, vol. 1, pp. 125–136, 1980.
  55. G. Cassady, D. T. Crouse, J. W. Kirklin et al., “A randomized, controlled trial of very early prophylactic ligation of the ductus arteriosus in babies who weighed 1000 g or less at birth,” New England Journal of Medicine, vol. 320, no. 23, pp. 1511–1516, 1989. View at Scopus
  56. S. E. Carlson, M. B. Montalto, D. L. Ponder, S. H. Werkman, and S. B. Korones, “Lower incidence of necrotizing enterocolitis in infants fed a preterm formula with egg phospholipids,” Pediatric Research, vol. 44, no. 4, pp. 491–498, 1998. View at Scopus
  57. V. Carrion and E. A. Egan, “Prevention of necrotisingenterocolitis,” Journal of Pediatric Gastroenterology and Nutrition, vol. 11, pp. 317–323, 1990.
  58. A. M. Kosloske, “Surgey of necrotisingenterocolitis,” World Journal of Surgery, vol. 9, pp. 277–284, 1985.
  59. A. Bütter, H. Flageole, and J. M. Laberge, “The changing face of surgical indications for necrotizing enterocolitis,” Journal of Pediatric Surgery, vol. 37, no. 3, pp. 496–499, 2002. View at Publisher · View at Google Scholar · View at Scopus
  60. A. Pierro, “The surgical management of necrotising enterocolitis,” Early Human Development, vol. 81, no. 1, pp. 79–85, 2005. View at Publisher · View at Google Scholar · View at Scopus
  61. A. B. Hoyos, “. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit.,” International Journal of Infectious Diseases, vol. 3, Article ID 197e202, 1999.
  62. H. C. Lin, B. H. Su, A. C. Chen, T. W. Lin, C. H. Tsai, and T. F. Yeh, “Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants,” Pediatrics, vol. 115, article 1e4, 2005.
  63. A. Bin-Nun, R. Bromiker, M. Wilschanski, M. Kaplan, B. Rudensky, and M. Caplan, “Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates,” Journal of Pediatrics, vol. 147, Article ID 192e6, 2005.
  64. H. C. Lin, C. H. Hsu, H. L. Chen, M. Y. Chung, J. F. Hsu, and R. I. Lien, “Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial,” Pediatrics, vol. 122, Article ID 693e700, 2008.