Table 2: Clinical trials of probiotic preparations to decrease the incidence of neonatal NEC.

StudySite/patient populationProbiotic administrationDecrease in NEC

Hoyos et al. [61]Bogota Columbia all admitted newborns historical controls singal site-1237 infantsDaily infloran until D/C (L acidophilus, B. infantis)2.9% versus 6.6%

Lin et al. [62]Taiwan VLBW < 1500 g prospective, masked randomized control trial singal site-367 infants2X/day infloran until D/C (L acidophilus, B. infantis)1% versus 5.3%

Bin-Nun et al. [63]Israel VLBW < 1500 g prospective, masked randomized control trial singal site-145 infantsDaily Abc Dophilus until 36 wks postconceptual age (B. infantis, Strep thermophilus, B. Bifidus)1% versus 14%

Lin et al. [64]Taiwan VLBW < 1500 g prospective, masked randomized control trial multicentre-434 infants2X/day infloran until D/C (L acidophilus, B. infantis)1.8% versus 6.5%